PATHOLOGY- MEDICAL DEPARTMENT
Pathology Syllabus
(These syllabus may change from time to time. Please check with the relevant Public Service Commission websites for any changes in the syllabus)
1 Cell Injury 2 Inflammation and repair 3 Immunopathology 4 Infectious diseases 5 Circulatory disturbances 6 Growth disturbances 7 Miscellaneous disorders 8 Haematopathology 9 Cardiovascular Pathology 10 Respiratory Pathology 11 Renal & Urinary tract pathology 12 Pathology of Gastrointestinal tract 13 Liver and Billiary tract pathology 14 Lymphoreticular System 15 Reproductive system 16 Osteopathology 17 Endocrine pathology 18 Neuropathology 19 Dermato-pathology 20 Tumours of soft tissues 21 Molecular genetics 22 Cytopathology 23 Laboratory Hi-tech instruments 24 Rational use & safe Blood Transfusion 25 Lab Biomedical Waste 26 Antibody-mediated rejection of solid organ allografts. 27 The maternal death autopsy. 28 Classification and treatment of non-small-cell lung carcinoma. 29 Pathology of obesity. 30 Stratified medicine for cancer: the role of the histopathologist. 31 Mucosal pathology of the gastric cardia and Barrett's oesophagus. 32 Pathology of regenerative and neoplastic hepatocellular nodules. 33 Serrated lesions of colon and rectum. 34 An update on the pathology of chronic inflammatory bowel disease. 35 Diagnosis and therapy of gastrointestinal MALT lymphoma. 36 Medical revalidation for histopathologists. 37 Molecular testing for human papilloma virus. 38 Tensins in health and disease. 39 Pathology in the undergraduate curriculum. 40 Primary carcinoma of the salivary gland – Selected Recent Advances. 41 Cancer invasion and metastasis - The concept of epithetial mesenchymal transition. 42 Matrix metalloproteinases (MMP) in neoplastic progression – Where are we now? 43 Osteoarthritis – New concepts 44 Cutaneous pseudolymphoma. 45 Liquid based cytology for Cervical Screening. 46 Pitfall in the diagnoses of Soft tissue tumours of childhood. 47 Sudden unexpected death in Infancy. 48 The Non invasive or minimally invasive autopsy. 49 Bio-terrorism. 50 Predictive and prognostic molecular markers in breast cancer. 51 Digital photography in histopathology. 52 Adult stem cells and trans differentiation. 53 Role of Immuno histochemistry in problematic prostate biopsy. 54 Cytokeratin immunostaining profile in diagnostic pathology. |
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PATHOLOGY MCQs
Ques # :1
The Fenton reaction leads to free radical generation when :
1) Radiant energy is absorbed by water
2) Hydrogen Peroxide is formed by Myeloperoxidase
3) Ferrous ion are converted to Ferric ions
4) Nitric Oxide is converted to peroxynitrate anion
Ans: 3
Ques # :2
Russell bodies are seen in:
1) Lymphocytes
2) Neutrophils
3) Macrophages
4) Plasma cell
Ans: 4
Ques # :3
Neutrophil secretes:
1) Lysosomal enzyme
2) Superoxide dismutase
3) Catalase
4) Cathepsin
Ans: 1
Ques # :4
Crooke's hyaline body is presented in
1) Yellow fever
2) Basophil cells of the pituitary glans in cushing syndrome
3) Parkinsonism
4) Huntington's disease
Ans: 2
Ques # :5
Which of the following statement about Telomerase is true
1) Has RNA polymerase activity
2) Causes carcinogenasis
3) Present in somatic cells
4) Absent in germ cells
Ans: 2
Ques # :6
Pyroptosis has all the features except
1) occurs in cells infected by microbes
2) Activation of capase-1
3) Generates biologically active IL-1
4) Triggered by viral proteins of RNA and DNA virus
Ans: 4
Ques # :7
Oxygen dependent killing is done through :
1) NADPH oxidase
2) Superoxide dismutase
3) Catalase
4) Glutathione peroxidase
Ans: 1
Ques # :8
Which are of the following is most important diapedesis
1) PECAM-1
2) Selectin
3) Integrin
4) Mucin like glycoprotein
Ans: 1
Ques # :9
Which of the following is not an inflammatory mediator
1) Tumour Necrosis factor
2) Myeloperoxidase
3) Interferons
4) Interleukin
Ans: 2
Ques # :10
Lewis triple response is caused due to:
1) Histamine
2) Axon reflex
3) injury to endothelium
4) Increased permeability
Ans: 1
Ques # :11
Which complement fragments are called anaphylatoxins?
1) C3a and C3b
2) C3b and C5b
3) C5a and C3b
4) C3a and C5a
Ans: 4
Ques # :12
Cryoprecipitate is rich in which of the following clotting factors:
1) Factor II
2) Factor V
3) Factor VII
4) Factor VIII
Ans: 4
Ques # :13
Opsonins are :
1) C3a
2) Ig M
3) Carbohydrate binding proteins
4) Selectins
Ans: 3
Ques # :14
The following type of renal calculi are radiolucent
1) Calcium oxalate
2) Struvite
3) Uric acid
4) Calcium phosphate
Ans: 3
Ques # :15
Prion disease is caused by:
1) Misfolding of proteins
2) Denaturation of Proteins
3) Reduced formation of proteins
4) Excess formation of proteins
Ans: 1
Ques # :16
Who established the concept of chemical substances such as histamine (produced in response to injury) mediate the vascular changes of inflammation:
1) Celsus
2) Rudolf virchow
3) Sir Thomas Levis
4) Elie Metchnikoff
Ans: 3
Ques # :17
All endothelial cells produce thrmbomodulin except those found in :
1) Hepatic circulation
2) Cuteneous circulation
3) Cerebral Microcirculation
4) Renal circulation
Ans: 3
Ques # :18
Lung abscess secondary to aspiration pneumonia develops more often in:
1) Lower lobe of right lung
2) Lower lobe of left lung
3) Upper lobe of either lung
4) Middle lobe of right lung
Ans: 1
Ques # :19
Congenital hypercoagulability states are all of the following EXCEPT:
1) Protein C deficiency
2) Protein S deficiency
3) Anti-phospholipid antibody syndrome
4) MTHFR gene mutation
Ans: 3
Ques # :20
Arterial Thrombosis is seen in:
1) Anti-phospholipid antibody syndrome
2) Protein S deficiency
3) Protein C deficiency
4) Antithrombin III deficiency
Ans: 1
Ques # :21
The initiating mechnism in endotoxic shock is
1) Peripheral vasodilation
2) Endothelial injury
3) Increased vascular permeability
4) Reduced cardiac output
Ans: 2
Ques # :22
Characteristic inclusion seen in parkinsonism are
1) Hirano bodies
2) Nerofibrillary tangle
3) Negri bodies
4) Lewy bodies
Ans: 4
Ques # :23
Which of the following disorder has been shown to be genetically transmitted by single autosomal dominant gene
1) Catatonic Schizophrenia
2) Phenylketonuria
3) Creutzfeldt- Jakob's disease
4) Huntington's disease
Ans: 4
Ques # :24
Which one is NOT a feature of cystic fibrosis?
1) Autosomal recessive disease
2) Abnormal chloride transport
3) affects intestine only
4) Increased risk of pulmonary infections
Ans: 3
Ques # :25In prader Willi syndrome , which one of the folllowing is increased?
1) LH
2) FSH
3) TSH
4) Ghrelin
Ans: 4
Ques # :26
Which one of the following type of bronchigenic carcinoma has the worst prognosis
1) Squamous cell carcinoma
2) Small cell carcinoma
3) Large cell carcinoma
4) Adenocarcinoma
Ans: 2
Ques # :27
Which of the following techniques can be used to detect exact localisation of a genetic locus
1) Chromosome painting
2) FISH
3) Comaparative genomic hybridization
4) Western blot
Ans: 2
Ques # :28
Gene for Wilm's tumour is located on:
1) Chromosome 1
2) Chromosome 10
3) Chromosome 11
4) Chromosome 12
Ans: 3
Ques # :29
What does a Ames test evaluate?
1) Experimental induction
2) Test for mutagenicity
3) Carcinogenasis by ionizing radiation
4) viral carcinogenesis
Ans: 2
Ques # :30
F body is
1) X chromatin
2) Y chromatin
3) Chromosome 11
4) Chromosome 21
Ans: 2
Ques # :31
Rh incompatibility disease of newborn means:
1) Type 1 Hypersensitivity
2) Type 2 Hypersensitivity
3) Type 3 Hypersensitivity
4) Type 4 Hypersensitivity
Ans: 2
Ques # :32
Migratory thrombophlebitis is associated with all of the following malignancies except:
1) Prostate
2) Lung
3) GIT
4) Pancreas
Ans: 1
Ques # :33
Tumour that follows rule of 10 is :
1) Pheochrmocytoma
2) Oncocytoma
3) Lymphoma
4) Renal cell carcinoma
Ans: 1
Ques # :34
Epidermal growth factor receptor 1(EGFR 1) is NOT involved in one of the following cancers:
1) Lung
2) Head & Neck
3) Breast
4) Liver
Ans: 4
Ques # :35
Which of the following mutation is seen in malignant Melanoma?
1) N-myc
2) CDKN2A
3) RET
4) Rb
Ans: 2
Ques # :36
The term pseudomalignant osseous tumour is used for the following condition:
1) Myositis ossificans
2) Osteochondroma
3) Osteoid osteoma
4) Osteoblastoma
Ans: 1
Ques # :37
Which one is not correctly paired
1) SMA- smooth muscle tumour
2) S-100-Skeletal Muscle tumour
3) Factor VIII- vascular tumour
4) LCA - Lymphoid cells
Ans: 2
Ques # :38
Perforins are produced by:
1) Cytotoxic T cells
2) Suppressor T cells
3) Memory helper T cells
4) Plasma cell
Ans: 1
Ques # :39
NK cells express:
1) CD 15, CD 55
2) Cd 16, CD 56
3) Cd 16, CD 57
4) Cd 21, CD 66
Ans: 2
Ques # :40
Which of the following type of hypersensitivity reaction is found in blood transfusion reaction
1) Anaphylatic type
2) Cytotoxic type
3) Type 3 Hypersensitivity
4) Cell mediated hypersensitivity
Ans: 2
Ques # :41Myasthenia gravis is most commonly associated with which of the following?
1) Thymoma
2) Thymic carcinoma
3) Thymic hyperplasia
4) Lymphoma
Ans: 3
Ques # :42
Anti- topoisomerase is marker of:
1) Systemic sclerosis
2) Classic polyarteritis nodosa
3) Nephrotic syndrome
4) Rheumatoid arthritis
Ans: 1
Ques # :43
"Macropolycytes" in peripheral smear is a feature of:
1) Hereditary spherocytosis
2) Iron deficiency anemia
3) Sickle cell anemia
4) Megaloblastic anemia
Ans: 4
Ques # :44
Mircroangiopathic haemolytic anemia seen in all except:
1) Thrombotic thrombocytopenic purpura
2) Hemolytic uremic syndrome
3) Henoch- Schonlein purpura
4) DIC
Ans: 3
Ques # :45
Paroxysmal nocturnal haemoglobinuria (PNH) due to defect in:
1) CD 59
2) CD 15
3) CD 100
4) CD 20
Ans: 1
Ques # :46
Which is the most common cytogenatic abnormalities in adult myelodyplastic syndrome
1) Trisomy 8
2) 20 q-
3) 5 q-
4) Monosomy 7
Ans: 3
Ques # :47
What is the chromosomal translocation in AML M3:
1) t(18,21)
2) t(15;17)
3) t(8,21)
4) t(9,11)
Ans: 2
Ques # :48
Mantle cell lymphomas are positive for all of the following except:
1) CD 23
2) CD 20
3) CD 5
4) Cyclin D1
Ans: 1
Ques # :49
All are B cell lymphomas except :
1) Burkitt's lymphoma
2) Mycosis fungoides
3) Mantle cell lymphoma
4) Follicular cell lymphoma
Ans: 2
Ques # :50
Proliferation and survival of myeloma cells are dependent on which of the following cytokines?
1) IL-1
2) IL-6
3) IL-2
4) IL-5
Ans: 2
The Fenton reaction leads to free radical generation when :
1) Radiant energy is absorbed by water
2) Hydrogen Peroxide is formed by Myeloperoxidase
3) Ferrous ion are converted to Ferric ions
4) Nitric Oxide is converted to peroxynitrate anion
Ans: 3
Ques # :2
Russell bodies are seen in:
1) Lymphocytes
2) Neutrophils
3) Macrophages
4) Plasma cell
Ans: 4
Ques # :3
Neutrophil secretes:
1) Lysosomal enzyme
2) Superoxide dismutase
3) Catalase
4) Cathepsin
Ans: 1
Ques # :4
Crooke's hyaline body is presented in
1) Yellow fever
2) Basophil cells of the pituitary glans in cushing syndrome
3) Parkinsonism
4) Huntington's disease
Ans: 2
Ques # :5
Which of the following statement about Telomerase is true
1) Has RNA polymerase activity
2) Causes carcinogenasis
3) Present in somatic cells
4) Absent in germ cells
Ans: 2
Ques # :6
Pyroptosis has all the features except
1) occurs in cells infected by microbes
2) Activation of capase-1
3) Generates biologically active IL-1
4) Triggered by viral proteins of RNA and DNA virus
Ans: 4
Ques # :7
Oxygen dependent killing is done through :
1) NADPH oxidase
2) Superoxide dismutase
3) Catalase
4) Glutathione peroxidase
Ans: 1
Ques # :8
Which are of the following is most important diapedesis
1) PECAM-1
2) Selectin
3) Integrin
4) Mucin like glycoprotein
Ans: 1
Ques # :9
Which of the following is not an inflammatory mediator
1) Tumour Necrosis factor
2) Myeloperoxidase
3) Interferons
4) Interleukin
Ans: 2
Ques # :10
Lewis triple response is caused due to:
1) Histamine
2) Axon reflex
3) injury to endothelium
4) Increased permeability
Ans: 1
Ques # :11
Which complement fragments are called anaphylatoxins?
1) C3a and C3b
2) C3b and C5b
3) C5a and C3b
4) C3a and C5a
Ans: 4
Ques # :12
Cryoprecipitate is rich in which of the following clotting factors:
1) Factor II
2) Factor V
3) Factor VII
4) Factor VIII
Ans: 4
Ques # :13
Opsonins are :
1) C3a
2) Ig M
3) Carbohydrate binding proteins
4) Selectins
Ans: 3
Ques # :14
The following type of renal calculi are radiolucent
1) Calcium oxalate
2) Struvite
3) Uric acid
4) Calcium phosphate
Ans: 3
Ques # :15
Prion disease is caused by:
1) Misfolding of proteins
2) Denaturation of Proteins
3) Reduced formation of proteins
4) Excess formation of proteins
Ans: 1
Ques # :16
Who established the concept of chemical substances such as histamine (produced in response to injury) mediate the vascular changes of inflammation:
1) Celsus
2) Rudolf virchow
3) Sir Thomas Levis
4) Elie Metchnikoff
Ans: 3
Ques # :17
All endothelial cells produce thrmbomodulin except those found in :
1) Hepatic circulation
2) Cuteneous circulation
3) Cerebral Microcirculation
4) Renal circulation
Ans: 3
Ques # :18
Lung abscess secondary to aspiration pneumonia develops more often in:
1) Lower lobe of right lung
2) Lower lobe of left lung
3) Upper lobe of either lung
4) Middle lobe of right lung
Ans: 1
Ques # :19
Congenital hypercoagulability states are all of the following EXCEPT:
1) Protein C deficiency
2) Protein S deficiency
3) Anti-phospholipid antibody syndrome
4) MTHFR gene mutation
Ans: 3
Ques # :20
Arterial Thrombosis is seen in:
1) Anti-phospholipid antibody syndrome
2) Protein S deficiency
3) Protein C deficiency
4) Antithrombin III deficiency
Ans: 1
Ques # :21
The initiating mechnism in endotoxic shock is
1) Peripheral vasodilation
2) Endothelial injury
3) Increased vascular permeability
4) Reduced cardiac output
Ans: 2
Ques # :22
Characteristic inclusion seen in parkinsonism are
1) Hirano bodies
2) Nerofibrillary tangle
3) Negri bodies
4) Lewy bodies
Ans: 4
Ques # :23
Which of the following disorder has been shown to be genetically transmitted by single autosomal dominant gene
1) Catatonic Schizophrenia
2) Phenylketonuria
3) Creutzfeldt- Jakob's disease
4) Huntington's disease
Ans: 4
Ques # :24
Which one is NOT a feature of cystic fibrosis?
1) Autosomal recessive disease
2) Abnormal chloride transport
3) affects intestine only
4) Increased risk of pulmonary infections
Ans: 3
Ques # :25In prader Willi syndrome , which one of the folllowing is increased?
1) LH
2) FSH
3) TSH
4) Ghrelin
Ans: 4
Ques # :26
Which one of the following type of bronchigenic carcinoma has the worst prognosis
1) Squamous cell carcinoma
2) Small cell carcinoma
3) Large cell carcinoma
4) Adenocarcinoma
Ans: 2
Ques # :27
Which of the following techniques can be used to detect exact localisation of a genetic locus
1) Chromosome painting
2) FISH
3) Comaparative genomic hybridization
4) Western blot
Ans: 2
Ques # :28
Gene for Wilm's tumour is located on:
1) Chromosome 1
2) Chromosome 10
3) Chromosome 11
4) Chromosome 12
Ans: 3
Ques # :29
What does a Ames test evaluate?
1) Experimental induction
2) Test for mutagenicity
3) Carcinogenasis by ionizing radiation
4) viral carcinogenesis
Ans: 2
Ques # :30
F body is
1) X chromatin
2) Y chromatin
3) Chromosome 11
4) Chromosome 21
Ans: 2
Ques # :31
Rh incompatibility disease of newborn means:
1) Type 1 Hypersensitivity
2) Type 2 Hypersensitivity
3) Type 3 Hypersensitivity
4) Type 4 Hypersensitivity
Ans: 2
Ques # :32
Migratory thrombophlebitis is associated with all of the following malignancies except:
1) Prostate
2) Lung
3) GIT
4) Pancreas
Ans: 1
Ques # :33
Tumour that follows rule of 10 is :
1) Pheochrmocytoma
2) Oncocytoma
3) Lymphoma
4) Renal cell carcinoma
Ans: 1
Ques # :34
Epidermal growth factor receptor 1(EGFR 1) is NOT involved in one of the following cancers:
1) Lung
2) Head & Neck
3) Breast
4) Liver
Ans: 4
Ques # :35
Which of the following mutation is seen in malignant Melanoma?
1) N-myc
2) CDKN2A
3) RET
4) Rb
Ans: 2
Ques # :36
The term pseudomalignant osseous tumour is used for the following condition:
1) Myositis ossificans
2) Osteochondroma
3) Osteoid osteoma
4) Osteoblastoma
Ans: 1
Ques # :37
Which one is not correctly paired
1) SMA- smooth muscle tumour
2) S-100-Skeletal Muscle tumour
3) Factor VIII- vascular tumour
4) LCA - Lymphoid cells
Ans: 2
Ques # :38
Perforins are produced by:
1) Cytotoxic T cells
2) Suppressor T cells
3) Memory helper T cells
4) Plasma cell
Ans: 1
Ques # :39
NK cells express:
1) CD 15, CD 55
2) Cd 16, CD 56
3) Cd 16, CD 57
4) Cd 21, CD 66
Ans: 2
Ques # :40
Which of the following type of hypersensitivity reaction is found in blood transfusion reaction
1) Anaphylatic type
2) Cytotoxic type
3) Type 3 Hypersensitivity
4) Cell mediated hypersensitivity
Ans: 2
Ques # :41Myasthenia gravis is most commonly associated with which of the following?
1) Thymoma
2) Thymic carcinoma
3) Thymic hyperplasia
4) Lymphoma
Ans: 3
Ques # :42
Anti- topoisomerase is marker of:
1) Systemic sclerosis
2) Classic polyarteritis nodosa
3) Nephrotic syndrome
4) Rheumatoid arthritis
Ans: 1
Ques # :43
"Macropolycytes" in peripheral smear is a feature of:
1) Hereditary spherocytosis
2) Iron deficiency anemia
3) Sickle cell anemia
4) Megaloblastic anemia
Ans: 4
Ques # :44
Mircroangiopathic haemolytic anemia seen in all except:
1) Thrombotic thrombocytopenic purpura
2) Hemolytic uremic syndrome
3) Henoch- Schonlein purpura
4) DIC
Ans: 3
Ques # :45
Paroxysmal nocturnal haemoglobinuria (PNH) due to defect in:
1) CD 59
2) CD 15
3) CD 100
4) CD 20
Ans: 1
Ques # :46
Which is the most common cytogenatic abnormalities in adult myelodyplastic syndrome
1) Trisomy 8
2) 20 q-
3) 5 q-
4) Monosomy 7
Ans: 3
Ques # :47
What is the chromosomal translocation in AML M3:
1) t(18,21)
2) t(15;17)
3) t(8,21)
4) t(9,11)
Ans: 2
Ques # :48
Mantle cell lymphomas are positive for all of the following except:
1) CD 23
2) CD 20
3) CD 5
4) Cyclin D1
Ans: 1
Ques # :49
All are B cell lymphomas except :
1) Burkitt's lymphoma
2) Mycosis fungoides
3) Mantle cell lymphoma
4) Follicular cell lymphoma
Ans: 2
Ques # :50
Proliferation and survival of myeloma cells are dependent on which of the following cytokines?
1) IL-1
2) IL-6
3) IL-2
4) IL-5
Ans: 2
Ques # :51
Platelet function defect is seen in all except:
1) Bernard Soulier syndrome
2) Wiskot Aldrich syndrome
3) von- Willebrand disease
4) Weber christian disease
Ans: 4
Ques # :52
The chromosomal translocation involving bcl-2 in B-cell lymphoma is:
1) t(8:14)
2) t(8:12)
3) t(14:18)
4) t(14:22)
Ans: 3
Ques # :53
Which of the following is the commonest histological finding I benign hypertension?
1) Proliferative end arteritis
2) Necrotizing arteriolitis
3) Hyaline arteriosclerosis
4) Cystic medial necrosis
Ans: 3
Ques # :54
Cystic medial necrosis is seen in
1) Marfan syndrome
2) Friedrichs ataxia
3) Down syndrome
4) Kawasaki disease
Ans: 1
Ques # :55
Which type of FSGS has the worst prgnosis?
1) Tip variant
2) Collapsing
3) NOS
4) Perihilar
Ans: 2
Ques # :56
Gluten sensitive enteropathy is most strongly associated with:
1) HLA-DQ2
2) HLA-DR4
3) HLA-DQ3
4) Blood group 'B'
Ans: 1
Ques # :57Rare histological variants of carcinoma breast with better prognosis include all except:
1) Colloid carcinoma
2) Medullary carcinoma
3) Inflammatory carcinoma
4) Tubular carcinoma
Ans: 3
Ques # :58
Programmed cell death is known as:
1) Cytolysis
2) Apoptosis
3) Necrosis
4) Proptosis
Ans: 2
Ques # :59
Liquefective necrosis is typically seen in :
1) Ischemic necrosis of heart
2) Ischemic necrosis of brain
3) Ischemic necrosis of intestine
4) Tuberculosis
Ans: 2
Ques # :60
Psammoma bodies are seen in all, except:
1) Follicular carcinoma of thyroid
2) Papillary carcinoma of thyroid
3) Serious systadenoma ovary
4) Meningioma
Ans: 1
Ques # :61
In acute inflammation of tissue, response consist of all except:
1) Vasodilation
2) Exudation
3) Neutrophillic response
4) Granuloma formation
Ans: 4
Ques # :62
Most important source of histamine
1) Mast cells
2) Neutrophil
3) Eosinophil
4) Macrophange
Ans: 1
Ques # :63
Cells most sensitive to hypoxia are :
1) Myocardial cells
2) Neurons
3) Hepatocytes
4) Renal tublar epithelial cells
Ans: 2
Ques # :64
Schiller-Duval bodies are seen in :
1) Teratoma
2) Seminoma
3) Yolk sac tumour
4) Chloriocarcinoma
Ans: 3
Ques # :65
Extrinsic pathway of clotting factor is measured by:
1) Prothrombin time
2) Activated partial Thromboplastin time
3) Bleeding time
4) Clotting time
Ans: 1
Ques # :66
Bleeding time is abnormal in :
1) Hemophilia
2) Christmas disease
3) von- Willebrand disease
4) Vitamin K deficiency
Ans: 3
Ques # :67
Most common site for Amoebiasis
1) Sigmoid colon
2) Transverse colon
3) Caecum & ascending colon
4) Liver
Ans: 3
Ques # :68
Reed Sternberg cells are seen in :
1) Hodgkins disease
2) Sickle cell anemia
3) Thalassemia
4) CML
Ans: 1
Ques # :69
Disseminated intravascular coagulation (DIC) is seen in
1) Acute Promyelocytic Leukemia
2) Acute Myelomonocytic Leukemia
3) Autoimmune hemolytic Anemia
4) CML
Ans: 1
Ques # :70
Wire loop lesions are seen in :
1) SLE
2) Diabetic nephropathy
3) Benign nephrosclerosis
4) Wegeners granulomatosis
Ans: 1
Ques # :71
Most common viral antigen used for diagnosis of HIV in blood before transfuion is :
1) P24
2) P17
3) P7
4) P14
Ans: 1
Ques # :72
Ringed Sideroblast are seen in:
1) Iron deficiency anemia
2) Myledysplastic syndrome
3) Thalassemia
4) Anemia of chronic disease
Ans: 2
Ques # :73
Autoimmune hemolytic anemia is seen in :
1) ALL
2) AML
3) CLL
4) CML
Ans: 3
Ques # :74
All are true about hashimoto's thyroiditis except:
1) Follicular destruction
2) Lymphocytic infiltration
3) Oncocytic Metaplasia
4) Orphan annie Eye Nucleus
Ans: 4
Ques # :75
Calcitonin is a marker of thyroid
1) Papillary carcinoma
2) Medullary carcinoma
3) Anaplastic carcinoma
4) Adeno carcinoma
Ans: 2
Ques # :76
Which of the following stains is used to detect Lipid in frozen section biopsy in histopathology laboratory
1) PAS
2) NSE
3) Oil Red O
4) Silver Methanemine
Ans: 3
Ques # :77
Most common salivary gland tumour in adult is :
1) Mucoepidermoid Carcinoma
2) Lymphoma
3) Plemorphic adenoma
4) None
Ans: 3
Ques # :78
Commonest cause of cerebral infarction is :
1) Arterial thombosis
2) Arteritis
3) Venous thombosis
4) Embolism
Ans: 1
Ques # :79
Most common site of Berry's Aneurysm is
1) Basilar artery
2) Anterior Communicating artery
3) Posterior Communicating artery
4) Posterior Cerebral artery
Ans: 2
Ques # :80
Most common CNS tumour is
1) Astrocytoma
2) Medulloblastoma
3) Meningioma
4) Oligodendroglioma
Ans: 1
Ques # :81
Aschoff's nodule is seen in :
1) Subacute Bacterial Endocarditis
2) Libman Sacks Endocarditis
3) Rheumatic carditis
4) Non bacterial thrombotic Endocarditis
Ans: 3
Ques # :82
Troponin-T is a marker of :
1) Renal disease
2) Muscular dystrophy
3) Cirrhosis of liver
4) Myocardial infraction
Ans: 4
Ques # :83
Medial calcification is seen in :
1) Atherosclerosis
2) Arteriosclerosis
3) Monckenberg sclerosis
4) Dissecting Aneurysm
Ans: 3
Ques # :84
Lung cancer is most commonly associated with
1) Asbestosis
2) Silicosis
3) Berylliosis
4) Coal worker pneumoconiosis
Ans: 1
Ques # :85
In Philadelphia chromosome the defect is in
1) Short arm of chromosome 22
2) Long arm of chromosome 22
3) Short arm of chromosome 9
4) Chromosome 21
Ans: 2
Ques # :86
Bence Jones Protein are
1) Light chain
2) Heavy chain
3) Medium chain
4) All of these
Ans: 1
Ques # :87
Skip lesions are seen in:
1) Ulcerative Colitis
2) Carcinoid syndrome
3) Crohn's disease
4) Whipple's disease
Ans: 3
Ques # :88
Which of the following having 90% association with HLAB27
1) Ankylosing Spondylitis
2) Psoriasis
3) Rheumatic arthritis
4) Reiter syndrome
Ans: 1
Ques # :89
Nutmeg liver is seen in:
1) Right sided heart failure
2) Left sided heart failure
3) High pulmonary pressure
4) Low pulmonary pressure
Ans: 1
Ques # :90
Hepatitis E is transmitted by:
1) Blood
2) Faeco-oral
3) Venereal
4) All of these
Ans: 2
Ques # :91
Varocay bodies are seen in
1) Meningioma
2) Hemangioma
3) Glioma
4) Schwannoma
Ans: 4
Ques # :92
Gleason's classification is used for
1) Carcinoma breast
2) Carcinoma prostate
3) Carcinoma pancreas
4) Carcinoma rectum
Ans: 2
Ques # :93
Fat embolism is commonly seen in :
1) Head injury
2) Long bone fracture
3) Drowning
4) Hanging
Ans: 2
Ques # :94
Lines of Zahn are found in:
1) Thrombus
2) Postmortem clot
3) Infarct tissue
4) All of these
Ans: 1
Ques # :95
Which of the following is an autosomal recessive condition
1) Ataxia Telangectasia
2) Neurofibromatosis
3) Peutz Jeghers syndrome
4) Tuberous sclerosis
Ans: 1
Ques # :96
The classic Karyotype of Klinefelter's syndrome is:
1) 47XXY
2) 48XXXX
3) 45XO
4) 46XY/47XXY
Ans: 1
Ques # :97
BRCA1 gene is located on
1) Chromosome 13
2) Chromosome 11
3) Chromosome 17
4) Chromosome 22
Ans: 3
Ques # :98
Retinoblastoma is assciated with which of the following tumor
1) Osteoclastoma
2) Hepatocellular carcinoma
3) Squamus carcinoma
4) Osteosarcoma
Ans: 4
Ques # :99
Heart failure cells are seen in following organ
1) Kidney
2) Heart
3) Lungs
4) Brain
Ans: 3
Ques # :100
Alpha fetoprotein is a marker of
1) Heptablastoma
2) Renal cell carcinoma
3) Seminoma
4) Chorio carcinoma
Ans: 1
Platelet function defect is seen in all except:
1) Bernard Soulier syndrome
2) Wiskot Aldrich syndrome
3) von- Willebrand disease
4) Weber christian disease
Ans: 4
Ques # :52
The chromosomal translocation involving bcl-2 in B-cell lymphoma is:
1) t(8:14)
2) t(8:12)
3) t(14:18)
4) t(14:22)
Ans: 3
Ques # :53
Which of the following is the commonest histological finding I benign hypertension?
1) Proliferative end arteritis
2) Necrotizing arteriolitis
3) Hyaline arteriosclerosis
4) Cystic medial necrosis
Ans: 3
Ques # :54
Cystic medial necrosis is seen in
1) Marfan syndrome
2) Friedrichs ataxia
3) Down syndrome
4) Kawasaki disease
Ans: 1
Ques # :55
Which type of FSGS has the worst prgnosis?
1) Tip variant
2) Collapsing
3) NOS
4) Perihilar
Ans: 2
Ques # :56
Gluten sensitive enteropathy is most strongly associated with:
1) HLA-DQ2
2) HLA-DR4
3) HLA-DQ3
4) Blood group 'B'
Ans: 1
Ques # :57Rare histological variants of carcinoma breast with better prognosis include all except:
1) Colloid carcinoma
2) Medullary carcinoma
3) Inflammatory carcinoma
4) Tubular carcinoma
Ans: 3
Ques # :58
Programmed cell death is known as:
1) Cytolysis
2) Apoptosis
3) Necrosis
4) Proptosis
Ans: 2
Ques # :59
Liquefective necrosis is typically seen in :
1) Ischemic necrosis of heart
2) Ischemic necrosis of brain
3) Ischemic necrosis of intestine
4) Tuberculosis
Ans: 2
Ques # :60
Psammoma bodies are seen in all, except:
1) Follicular carcinoma of thyroid
2) Papillary carcinoma of thyroid
3) Serious systadenoma ovary
4) Meningioma
Ans: 1
Ques # :61
In acute inflammation of tissue, response consist of all except:
1) Vasodilation
2) Exudation
3) Neutrophillic response
4) Granuloma formation
Ans: 4
Ques # :62
Most important source of histamine
1) Mast cells
2) Neutrophil
3) Eosinophil
4) Macrophange
Ans: 1
Ques # :63
Cells most sensitive to hypoxia are :
1) Myocardial cells
2) Neurons
3) Hepatocytes
4) Renal tublar epithelial cells
Ans: 2
Ques # :64
Schiller-Duval bodies are seen in :
1) Teratoma
2) Seminoma
3) Yolk sac tumour
4) Chloriocarcinoma
Ans: 3
Ques # :65
Extrinsic pathway of clotting factor is measured by:
1) Prothrombin time
2) Activated partial Thromboplastin time
3) Bleeding time
4) Clotting time
Ans: 1
Ques # :66
Bleeding time is abnormal in :
1) Hemophilia
2) Christmas disease
3) von- Willebrand disease
4) Vitamin K deficiency
Ans: 3
Ques # :67
Most common site for Amoebiasis
1) Sigmoid colon
2) Transverse colon
3) Caecum & ascending colon
4) Liver
Ans: 3
Ques # :68
Reed Sternberg cells are seen in :
1) Hodgkins disease
2) Sickle cell anemia
3) Thalassemia
4) CML
Ans: 1
Ques # :69
Disseminated intravascular coagulation (DIC) is seen in
1) Acute Promyelocytic Leukemia
2) Acute Myelomonocytic Leukemia
3) Autoimmune hemolytic Anemia
4) CML
Ans: 1
Ques # :70
Wire loop lesions are seen in :
1) SLE
2) Diabetic nephropathy
3) Benign nephrosclerosis
4) Wegeners granulomatosis
Ans: 1
Ques # :71
Most common viral antigen used for diagnosis of HIV in blood before transfuion is :
1) P24
2) P17
3) P7
4) P14
Ans: 1
Ques # :72
Ringed Sideroblast are seen in:
1) Iron deficiency anemia
2) Myledysplastic syndrome
3) Thalassemia
4) Anemia of chronic disease
Ans: 2
Ques # :73
Autoimmune hemolytic anemia is seen in :
1) ALL
2) AML
3) CLL
4) CML
Ans: 3
Ques # :74
All are true about hashimoto's thyroiditis except:
1) Follicular destruction
2) Lymphocytic infiltration
3) Oncocytic Metaplasia
4) Orphan annie Eye Nucleus
Ans: 4
Ques # :75
Calcitonin is a marker of thyroid
1) Papillary carcinoma
2) Medullary carcinoma
3) Anaplastic carcinoma
4) Adeno carcinoma
Ans: 2
Ques # :76
Which of the following stains is used to detect Lipid in frozen section biopsy in histopathology laboratory
1) PAS
2) NSE
3) Oil Red O
4) Silver Methanemine
Ans: 3
Ques # :77
Most common salivary gland tumour in adult is :
1) Mucoepidermoid Carcinoma
2) Lymphoma
3) Plemorphic adenoma
4) None
Ans: 3
Ques # :78
Commonest cause of cerebral infarction is :
1) Arterial thombosis
2) Arteritis
3) Venous thombosis
4) Embolism
Ans: 1
Ques # :79
Most common site of Berry's Aneurysm is
1) Basilar artery
2) Anterior Communicating artery
3) Posterior Communicating artery
4) Posterior Cerebral artery
Ans: 2
Ques # :80
Most common CNS tumour is
1) Astrocytoma
2) Medulloblastoma
3) Meningioma
4) Oligodendroglioma
Ans: 1
Ques # :81
Aschoff's nodule is seen in :
1) Subacute Bacterial Endocarditis
2) Libman Sacks Endocarditis
3) Rheumatic carditis
4) Non bacterial thrombotic Endocarditis
Ans: 3
Ques # :82
Troponin-T is a marker of :
1) Renal disease
2) Muscular dystrophy
3) Cirrhosis of liver
4) Myocardial infraction
Ans: 4
Ques # :83
Medial calcification is seen in :
1) Atherosclerosis
2) Arteriosclerosis
3) Monckenberg sclerosis
4) Dissecting Aneurysm
Ans: 3
Ques # :84
Lung cancer is most commonly associated with
1) Asbestosis
2) Silicosis
3) Berylliosis
4) Coal worker pneumoconiosis
Ans: 1
Ques # :85
In Philadelphia chromosome the defect is in
1) Short arm of chromosome 22
2) Long arm of chromosome 22
3) Short arm of chromosome 9
4) Chromosome 21
Ans: 2
Ques # :86
Bence Jones Protein are
1) Light chain
2) Heavy chain
3) Medium chain
4) All of these
Ans: 1
Ques # :87
Skip lesions are seen in:
1) Ulcerative Colitis
2) Carcinoid syndrome
3) Crohn's disease
4) Whipple's disease
Ans: 3
Ques # :88
Which of the following having 90% association with HLAB27
1) Ankylosing Spondylitis
2) Psoriasis
3) Rheumatic arthritis
4) Reiter syndrome
Ans: 1
Ques # :89
Nutmeg liver is seen in:
1) Right sided heart failure
2) Left sided heart failure
3) High pulmonary pressure
4) Low pulmonary pressure
Ans: 1
Ques # :90
Hepatitis E is transmitted by:
1) Blood
2) Faeco-oral
3) Venereal
4) All of these
Ans: 2
Ques # :91
Varocay bodies are seen in
1) Meningioma
2) Hemangioma
3) Glioma
4) Schwannoma
Ans: 4
Ques # :92
Gleason's classification is used for
1) Carcinoma breast
2) Carcinoma prostate
3) Carcinoma pancreas
4) Carcinoma rectum
Ans: 2
Ques # :93
Fat embolism is commonly seen in :
1) Head injury
2) Long bone fracture
3) Drowning
4) Hanging
Ans: 2
Ques # :94
Lines of Zahn are found in:
1) Thrombus
2) Postmortem clot
3) Infarct tissue
4) All of these
Ans: 1
Ques # :95
Which of the following is an autosomal recessive condition
1) Ataxia Telangectasia
2) Neurofibromatosis
3) Peutz Jeghers syndrome
4) Tuberous sclerosis
Ans: 1
Ques # :96
The classic Karyotype of Klinefelter's syndrome is:
1) 47XXY
2) 48XXXX
3) 45XO
4) 46XY/47XXY
Ans: 1
Ques # :97
BRCA1 gene is located on
1) Chromosome 13
2) Chromosome 11
3) Chromosome 17
4) Chromosome 22
Ans: 3
Ques # :98
Retinoblastoma is assciated with which of the following tumor
1) Osteoclastoma
2) Hepatocellular carcinoma
3) Squamus carcinoma
4) Osteosarcoma
Ans: 4
Ques # :99
Heart failure cells are seen in following organ
1) Kidney
2) Heart
3) Lungs
4) Brain
Ans: 3
Ques # :100
Alpha fetoprotein is a marker of
1) Heptablastoma
2) Renal cell carcinoma
3) Seminoma
4) Chorio carcinoma
Ans: 1
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