BIOCHEMISTRY-MEDICAL DEPARTMENT
BIOCHEMISTRY- MEDICAL DEPARTMENT SYLLABUS
(These syllabus may change from time to time. Please check with the relevant Public Service Commission websites for any changes in the syllabus)
1. Basic Laboratory Procedures: Disinfection, Laboratory safety, first aid. Biochemical samples and their collection, preservatives, anticoagulants. Preparation of solutions and reagents. Laboratory reporting systems, biological variations, chemical interference, Normal/reference range. Expression of results of biochemical investigations-various units. Quality management of laboratory- standardization and calibration. Biomedical waste disposal. Laboratory record keeping, Accreditation.
2. Biochemical Instruments/Technique: Colorimetry, Spectrophotometry, Fluorometry, Chromatography, Electrophoresis, Densitometer, Flame photometry, Electrolyte analyser, Blood gas analyser, Atomic absorption spectroscopy, RIA, ELISA, Gamma counter, Chemiluminescence assay, Water purification systems, Semi autoanalyser, Fully autoanalyser, PCR, HPLC, Blotting technique.
3. Estimation of various biochemical parameters.
4. Organ function tests: Liver, kidney, thyroid, pancreas, adrenocortical.
5. Chemistry, metabolism & Inborn errors of: (a) Carbohydrates (b) Lipids (c) Amino Acid & Proteins (d) Nucleotides
6. Enzymes
7. Vitamins
8. Mineral Metabolism and abnormalities
9. Acid-base balance & pH
10. Electrolyte and water balance.
11. Heme synthesis & Breakdown
12. Energy metabolism & Nutrition
13. Hormones
14. Environmental Biochemistry
15. Immunochemistry
16. Biochemistry of Cancer
17. Biochemistry of HIV & AIDS
1. Basic Laboratory Procedures: Disinfection, Laboratory safety, first aid. Biochemical samples and their collection, preservatives, anticoagulants. Preparation of solutions and reagents. Laboratory reporting systems, biological variations, chemical interference, Normal/reference range. Expression of results of biochemical investigations-various units. Quality management of laboratory- standardization and calibration. Biomedical waste disposal. Laboratory record keeping, Accreditation.
2. Biochemical Instruments/Technique: Colorimetry, Spectrophotometry, Fluorometry, Chromatography, Electrophoresis, Densitometer, Flame photometry, Electrolyte analyser, Blood gas analyser, Atomic absorption spectroscopy, RIA, ELISA, Gamma counter, Chemiluminescence assay, Water purification systems, Semi autoanalyser, Fully autoanalyser, PCR, HPLC, Blotting technique.
3. Estimation of various biochemical parameters.
4. Organ function tests: Liver, kidney, thyroid, pancreas, adrenocortical.
5. Chemistry, metabolism & Inborn errors of: (a) Carbohydrates (b) Lipids (c) Amino Acid & Proteins (d) Nucleotides
6. Enzymes
7. Vitamins
8. Mineral Metabolism and abnormalities
9. Acid-base balance & pH
10. Electrolyte and water balance.
11. Heme synthesis & Breakdown
12. Energy metabolism & Nutrition
13. Hormones
14. Environmental Biochemistry
15. Immunochemistry
16. Biochemistry of Cancer
17. Biochemistry of HIV & AIDS
BIOCHEMISTRY MCQs
Ques # :1
Which of the following is not a single membrane bound cell organelles
1) Golgi bodies
2) Ribosome
3) Peroxisomes
4) Lysosomes
Ans: 2
Ques # :2
Which of the following has the lowest glycemic index
1) Maltose
2) Fructose
3) Milk
4) Polished rice
Ans: 2
Ques # :3
The primary transporter for fructose in small intestine and testes:
1) GLUT-1
2) GLUT-5
3) GLUT-3
4) GLUT-2
Ans: 2
Ques # :4
The patients excrete milky urine in disorder
1) Ketonuria
2) Chyluria
3) Lactosuria
4) Galactosuria
Ans: 2
Ques # :5
Lysolecithin is formed from lecithin by the action of
1) Phospholipase A1
2) Phospholipase A2
3) Phospholipase C
4) Phospholipase D
Ans: 2
Ques # :6
Which of the following is considered as a dignostic marker for early apoptotis
1) Cardiolipin
2) Gangliosides
3) Cephalin
4) Aryl Sulphate
Ans: 1
Ques # :7
Allosteric inhibitor of gultamate dehydrogenase enzyme is
1) AMP
2) ATP
3) GMP
4) ADP
Ans: 2
Ques # :8
Ubiquitin is required for
1) Lysosomal degradation of proteins
2) Synthesis of ubiquinone
3) Cytosolic degradation of proteins
4) Synthesis of urea
Ans: 3
Ques # :9
The commited step in biosynthesis of pyrimidine is catalysed by
1) dihydrorotase
2) dihydrorotase dehydrogenase
3) Carbamoylphosphate synthetase
4) Aspartate transcarbamoylase
Ans: 4
Ques # :10
Which of the following has the strongest tendency to gain electrons
1) Co Enzyme Q
2) Cytochrome C
3) NAD
4) Oxygen
Ans: 4
Ques # :11
Acetyl CoA is an allosteric inhibitor of:
1) Succinate dehydrogenase
2) Malate dehydrogenase
3) Pyruvate dehydrogenase
4) Isocitrate dehydrogenase
Ans: 3
Ques # :12
Normal anion gap in plasma is about
1) 15 mEq/L
2) 10 mEq/L
3) 5 mEq/L
4) 0 mEq/L
Ans: 1
Ques # :13
pKa of dehydrogen phosphate is
1) 5.8
2) 6.1
3) 6.8
4) 7.1
Ans: 3
Ques # :14
Hypo-osmotic dehydration is the condition seen in :
1) Hypernatremia
2) Hyponatremia
3) Pulmonary edema
4) All
Ans: 2
Ques # :15
Congestive heart failure is characterized by
1) Increase plasma volume
2) Decreased plasma volume
3) Increased sodium loss
4) Decreased potassium retention
Ans: 1
Ques # :16
Osmoreceptors are present in
1) Capillaries
2) Aortic arch
3) Carotid sinus
4) Hypothalamus
Ans: 4
Ques # :17
Vitamin used in the management of hyperlipidemia
1) Niacin
2) Folic acid
3) Cobalamine
4) Thymine
Ans: 1
Ques # :18
Cystatin C is marker for
1) Distal tubular function
2) Renin angeotensin system
3) Glomerular function
4) none of them
Ans: 3
Ques # :19
Ferrochelatase is deficient in
1) Acute intermittent porphyria
2) Porphiria cutanea
3) Hereditary corproporphyria
4) Protoporphyria
Ans: 4
Ques # :20
A person on a fat free carbohydrate rich diet continues to grow obese. Which of the following lipoprotein is likely to be elevated in his blood
1) Chylomicrons
2) VLDL
3) LDL
4) HDL
Ans: 2
Ques # :21
The RDA for lipids per day for normal adults is:
1) 20 gms
2) 45 gms
3) 40 gms
4) 50 gms
Ans: 1
Ques # :22
Hormone response elements are located in:
1) Nucleus
2) Mitochondria
3) Cell membrane
4) Cytosol
Ans: 1
Ques # :23
CD 4 is a transmembrane protein present in
1) Plasma cells
2) Cytotoxic C cells
3) Helper T cells
4) Suppressor T cells
Ans: 3
Ques # :24
Antibodies are classified on the basis of their :
1) Size
2) Heavy chains
3) Light chains
4) Idiotypes
Ans: 2
Ques # :25
The antibody present in lowest concentration in plasma
1) Ig E
2) Ig D
3) Ig G
4) Ig A
Ans: 1
Ques # :26
The genes for the light chains of Immunoglobulins are located on chromosomes
1) 2 and 22
2) 2 and 14
3) 2 and 16
4) 2 and 10
Ans: 1
Ques # :27
Waldenstrom's macroglobulinemia occurs due to increase of
1) Ig A
2) Ig M
3) Ig D
4) Ig G
Ans: 2
Ques # :28
Ciprofloxacin inhibits the synthesis of :
1) m RNA
2) DNA
3) t RNA
4) r RNA
Ans: 2
Ques # :29
Which of the following is not a protein misfolding disorder
1) Tuberculosis
2) Alzheimer's disease
3) Cystic fibrosis
4) Prion disease
Ans: 1
Ques # :30
Which type of RNA has the highest percentage of modified base
1) m RNA
2) t RNA
3) r RNA
4) Sn RNA
Ans: 2
Which of the following is not a single membrane bound cell organelles
1) Golgi bodies
2) Ribosome
3) Peroxisomes
4) Lysosomes
Ans: 2
Ques # :2
Which of the following has the lowest glycemic index
1) Maltose
2) Fructose
3) Milk
4) Polished rice
Ans: 2
Ques # :3
The primary transporter for fructose in small intestine and testes:
1) GLUT-1
2) GLUT-5
3) GLUT-3
4) GLUT-2
Ans: 2
Ques # :4
The patients excrete milky urine in disorder
1) Ketonuria
2) Chyluria
3) Lactosuria
4) Galactosuria
Ans: 2
Ques # :5
Lysolecithin is formed from lecithin by the action of
1) Phospholipase A1
2) Phospholipase A2
3) Phospholipase C
4) Phospholipase D
Ans: 2
Ques # :6
Which of the following is considered as a dignostic marker for early apoptotis
1) Cardiolipin
2) Gangliosides
3) Cephalin
4) Aryl Sulphate
Ans: 1
Ques # :7
Allosteric inhibitor of gultamate dehydrogenase enzyme is
1) AMP
2) ATP
3) GMP
4) ADP
Ans: 2
Ques # :8
Ubiquitin is required for
1) Lysosomal degradation of proteins
2) Synthesis of ubiquinone
3) Cytosolic degradation of proteins
4) Synthesis of urea
Ans: 3
Ques # :9
The commited step in biosynthesis of pyrimidine is catalysed by
1) dihydrorotase
2) dihydrorotase dehydrogenase
3) Carbamoylphosphate synthetase
4) Aspartate transcarbamoylase
Ans: 4
Ques # :10
Which of the following has the strongest tendency to gain electrons
1) Co Enzyme Q
2) Cytochrome C
3) NAD
4) Oxygen
Ans: 4
Ques # :11
Acetyl CoA is an allosteric inhibitor of:
1) Succinate dehydrogenase
2) Malate dehydrogenase
3) Pyruvate dehydrogenase
4) Isocitrate dehydrogenase
Ans: 3
Ques # :12
Normal anion gap in plasma is about
1) 15 mEq/L
2) 10 mEq/L
3) 5 mEq/L
4) 0 mEq/L
Ans: 1
Ques # :13
pKa of dehydrogen phosphate is
1) 5.8
2) 6.1
3) 6.8
4) 7.1
Ans: 3
Ques # :14
Hypo-osmotic dehydration is the condition seen in :
1) Hypernatremia
2) Hyponatremia
3) Pulmonary edema
4) All
Ans: 2
Ques # :15
Congestive heart failure is characterized by
1) Increase plasma volume
2) Decreased plasma volume
3) Increased sodium loss
4) Decreased potassium retention
Ans: 1
Ques # :16
Osmoreceptors are present in
1) Capillaries
2) Aortic arch
3) Carotid sinus
4) Hypothalamus
Ans: 4
Ques # :17
Vitamin used in the management of hyperlipidemia
1) Niacin
2) Folic acid
3) Cobalamine
4) Thymine
Ans: 1
Ques # :18
Cystatin C is marker for
1) Distal tubular function
2) Renin angeotensin system
3) Glomerular function
4) none of them
Ans: 3
Ques # :19
Ferrochelatase is deficient in
1) Acute intermittent porphyria
2) Porphiria cutanea
3) Hereditary corproporphyria
4) Protoporphyria
Ans: 4
Ques # :20
A person on a fat free carbohydrate rich diet continues to grow obese. Which of the following lipoprotein is likely to be elevated in his blood
1) Chylomicrons
2) VLDL
3) LDL
4) HDL
Ans: 2
Ques # :21
The RDA for lipids per day for normal adults is:
1) 20 gms
2) 45 gms
3) 40 gms
4) 50 gms
Ans: 1
Ques # :22
Hormone response elements are located in:
1) Nucleus
2) Mitochondria
3) Cell membrane
4) Cytosol
Ans: 1
Ques # :23
CD 4 is a transmembrane protein present in
1) Plasma cells
2) Cytotoxic C cells
3) Helper T cells
4) Suppressor T cells
Ans: 3
Ques # :24
Antibodies are classified on the basis of their :
1) Size
2) Heavy chains
3) Light chains
4) Idiotypes
Ans: 2
Ques # :25
The antibody present in lowest concentration in plasma
1) Ig E
2) Ig D
3) Ig G
4) Ig A
Ans: 1
Ques # :26
The genes for the light chains of Immunoglobulins are located on chromosomes
1) 2 and 22
2) 2 and 14
3) 2 and 16
4) 2 and 10
Ans: 1
Ques # :27
Waldenstrom's macroglobulinemia occurs due to increase of
1) Ig A
2) Ig M
3) Ig D
4) Ig G
Ans: 2
Ques # :28
Ciprofloxacin inhibits the synthesis of :
1) m RNA
2) DNA
3) t RNA
4) r RNA
Ans: 2
Ques # :29
Which of the following is not a protein misfolding disorder
1) Tuberculosis
2) Alzheimer's disease
3) Cystic fibrosis
4) Prion disease
Ans: 1
Ques # :30
Which type of RNA has the highest percentage of modified base
1) m RNA
2) t RNA
3) r RNA
4) Sn RNA
Ans: 2
Ques # :31
The first gene therapy in human was carried out by French Anderson in:
1) 1990
2) 1970
3) 1980
4) 1995
Ans: 1
Ques # :32
Aging cell will release iron with the help of a copper containing protein called
1) Hepcidin
2) Hephaestin
3) Hemosiderin
4) Hemopexin
Ans: 2
Ques # :33
Which monosaccharide causes sequestering of phosphate in cell
1) Glucose
2) Fructose
3) Ribose
4) Galactose
Ans: 2
Ques # :34
Amino acid with thio-ether group is
1) Cysteine
2) Histidine
3) Methionine
4) Threonine
Ans: 3
Ques # :35
Hydrolysis of ATP into ADP and Pi liberates energy of
1) 3.4 kcal/mol
2) 5.0 kcal/mol
3) 7.3 kcal/mol
4) 10.3 kcal/mol
Ans: 3
Ques # :36
Enzyme used as a therapeutic agent
1) Asparaginase
2) Gamma glutamyltransferase
3) Taq Polymerase
4) Restriction endonuclease
Ans: 1
Ques # :37
Which molecular form of vitamine- A has role in skin disease
1) Beta-carotene
2) Retinol
3) Retinoic acid
4) Retinal
Ans: 3
Ques # :38
Peptide linkage is present in which vitamine structure
1) Riboflavin
2) Pantothenic acid
3) Biotin
4) Niacin
Ans: 2
Ques # :39
Iodide pump in thyroid gland functions by:
1) Primary active transport system
2) Carrier type transport system
3) Vesicular type transport system`
4) Secondary active transport system
Ans: 4
Ques # :40
Detoxification of methanol and ethanol is done through
1) Hydrolysis
2) Oxidation
3) Reduction
4) Conjugation
Ans: 2
Ques # :41
Major cause of metabolic acidosis is:
1) Overdose of narcotics
2) Potassium deficiency
3) Hepatic failure
4) Diabetic ketoacidosis
Ans: 4
Ques # :42
Specific Dynamic Action(SDA) is highest for
1) Carbohydrates
2) Lipids
3) Proteins
4) Vitamins
Ans: 3
Ques # :43
Dietary fibers have beneficial effects in:
1) Cancers
2) Diabetes mellitus
3) Obesity
4) All of them
Ans: 4
Ques # :44
Trace metal used for prevention of peroxidation of lipids
1) Selenium
2) Chromium
3) Cobalt
4) Molybdenum
Ans: 1
Ques # :45
Disease associated with impaired synthesis of collagen protein
1) Scurvy
2) Alport syndrome
3) Ehlers-Danlos syndrome
4) all of them
Ans: 4
Ques # :46
Pauly's test is for the presence of
1) Histidine
2) Arginine
3) Tyrosine
4) Tryptophan
Ans: 1
Ques # :47
Allopurinol is structural analog of:
1) Hypoxanthine
2) Xanthine
3) Uric acid
4) Alloxanthine
Ans: 1
Ques # :48
In myocardial infaction serum level of the which LDH enzyme is elevated :
1) LDH-1
2) LDH-3
3) LDH-4
4) LDH-5
Ans: 1
Ques # :49
Hydroxylatiom of 25-hydroxycholecalciferol by 1-α hydroxylase occurs in :
1) Skin
2) Liver
3) Kidneys
4) Intestine
Ans: 3
Ques # :50
Eating excess raw eggs causes deficiency of
1) Riboflavin
2) Niacin
3) Folic acid
4) Biotin
Ans: 4
Ques # :51
A salivary protein Gusten contains
1) Zinc
2) Manganese
3) Selenium
4) Chromium
Ans: 1
Ques # :52
The tubular maximum for glucose (TmG) is
1) .350 mg/min
2) .350 mg/dl
3) .350 mg/ml
4) .350 ml/min
Ans: 1
Ques # :53
Porphyria inherited as autosomal recessive disorder :
1) Erythropoietic protoporphyria
2) Congenital erythropoietic porphyria
3) Acute intermittent porphyria
4) Variegate porphyria
Ans: 2
Ques # :54
Achlorhydria condition is seen in:
1) Zollinger-Ellison syndrome
2) Gastric Carcinoma
3) Pernicious anemia
4) Duodenal ulcer
Ans: 3
Ques # :55
Water excretion by kidneys is tightly regulated by:
1) Aldosterone
2) Epinephrine
3) Oxytocin
4) Vasopressin
Ans: 4
Ques # :56
In replication the function of following enzyme is comparable with Zip opener
1) DNA Liagase
2) DNA Helicase
3) DNA Gyrase
4) DNA topoisomerase
Ans: 2
Ques # :57
In translation, the number of high energy phosphate bonds used for incorporating a single
amino acid is
1) 3
2) 4
3) 5
4) 6
Ans: 2
Ques # :58
Oncogenic virus which is not a DNA virus
1) Adenovirus
2) Papovirus
3) Retro virus
4) Herpes virus
Ans: 3
Ques # :59
Seperation of molecules in electrophoresis depends on
1) Size
2) Charge
3) Magnitude of current
4) All of them
Ans: 4
Ques # :60
Prostanoids includes all EXCEPT
1) Prostacyclins
2) Lipoxins
3) Thromboxanes
4) Prostaglandin
Ans: 2
Ques # :61
Triple Helix structure is seen in
1) Collagen
2) Silk
3) Myoglobin
4) Hemoglobin
Ans: 1
Ques # :62
Trehalose is :
1) Non reducing disaccharide
2) Major sugar of insect hemolymph
3) Hydrolyzed into two-α glucose molecule
4) All of them
Ans: 4
Ques # :63
The Phase-I biotransformation includes all reactions except
1) Oxidation
2) Conjugation
3) Hydrolysis
4) Reduction
Ans: 2
Ques # :64
Release of which hormone from endronic gland is facilitated by calcium ions
1) Insulin
2) PTH
3) Calcitonin
4) All of them
Ans: 4
Ques # :65
Hypoxia Occuring in high altitudes causes
1) Metabolic acidosis
2) Respiratory alkalosis
3) Metabolic acidosis
4) Respiratory acidosis
Ans: 2
Ques # :66
Increased urinary excretion of uroblinogen is observed in
1) Hemolytic jaundice
2) Hepatic jaundice
3) Obstructive jaundice
4) All of them
Ans: 1
Ques # :67
Kidneys regulate electrolyte balance through
1) Aldosterone
2) Atrial natriuretic factor
3) Bradykinin and Kallidin
4) All of them
Ans: 4
Ques # :68
Clinical manifestation of Kwashiorkor includes EXCEPT
1) Oedema
2) Diarrhoea
3) Moon face
4) Emaciation
Ans: 4
Ques # :69
Minamata disease is due to toxicity of:
1) Mercury
2) Arsenic
3) Cadmium
4) Lead
Ans: 1
Ques # :70
Which immunoglobulin mediates primary immune response
1) Ig G
2) Ig A
3) Ig M
4) Ig D
Ans: 3
Ques # :71
High degree of fidelity during replication is maintained by:
1) DNA topoisomerase
2) DNA Helicase
3) DNA polymerase
4) DNA ligase
Ans: 3
Ques # :72
The promotors elements of transcription are present on:
1) Template strand
2) Coding strand
3) RNA polymerase
4) hn-RNA
Ans: 2
Ques # :73
Which one is antioncogene:
1) c-ras
2) v-ras
3) c-myc
4) RB1
Ans: 4
Ques # :74
All the following are glycoproteins EXCEPT:
1) TSH
2) Globosides
3) Alkaline Phosphotase
4) Lectins
Ans: 2
Ques # :75
The property of surface tension is applied in all processes except:
1) Digestion and Absorption of fats
2) Exchange of gases in lungs
3) Oedema due to hypoalbuminemia
4) Detections of bile salts in urine
Ans: 3
Ques # :76
One amino acid may have more than one codon. The property of genetic code is :
1) Degeneracy
2) Specificity
3) Universality
4) Unambiguity
Ans: 1
Ques # :77
Tumour marker associated with carcinoma thyroid gland:
1) Alphafetoprotein
2) CA-125
3) Calcitonin
4) Neuron specific enolase
Ans: 3
Ques # :78
Hormone that causes obesity
1) Laptin
2) Ghrelin
3) Adiponectin
4) PYY-36
Ans: 2
Ques # :79
Compound acting as inhibitor of complex-I of electron transport chain
1) Malonate
2) Amobarbital
3) Antimycin-A
4) Cyanide
Ans: 2
Ques # :80
Level of structural organization preserved during denaturation of proteins:
1) Primary
2) Secondary
3) Tertiary
4) Quaternary
Ans: 1
Ques # :81
Cardiolipin is associated with
1) Barth syndrome
2) Parkinson's disease
3) Tangier's disease
4) All of them
Ans: 4
Ques # :82
The nitrogen atoms in urea originates from:
1) Ammonia and alanine
2) Ammonia and glutamine
3) Glutamate and aspartate
4) Alanine and aspartate
Ans: 3
Ques # :83
Barlows disease is due to deficiency of :
1) Vitamin-A
2) Vitamin-C
3) Vitamin-K
4) Vitamin-B3
Ans: 2
Ques # :84
Argentaffinomas in malignant carcinoid are usually seen in cells of :
1) Brain
2) Gastrointestinal tract
3) Heart
4) Lungs
Ans: 2
Ques # :85
The compound providing color to stool is :
1) Bilirubin
2) Stercobilinogen
3) Stercobilin
4) Urobilinogen
Ans: 3
Ques # :86
the amino acid required for the synthesis of Nitric oxide
1) Alanine
2) Argininoosuccinate
3) Tryptophan
4) Arginine
Ans: 4
Ques # :87
Regulatory gene in Lac-operon is:
1) Lac-I
2) Lac-Z
3) Lac-Y
4) Lac-A
Ans: 1
Ques # :88
Inhibition of glycolysis by oxygen is known as:
1) Krebs effect
2) Hills effect
3) Cori's effect
4) Pasteur effect
Ans: 4
Ques # :89
The hormone that stimulates mammotropic and lactogenic action is
1) TSH
2) Prolactin
3) LH
4) Progestrone
Ans: 2
Ques # :90
The Biochemical marker for the assessment of lipid peroxidation is:
1) Hydroperoxide
2) Reactive hydrogen species
3) Malondialdehyde
4) Ceruloplasmin
Ans: 3
Ques # :91
The nucleotide used in the treatment of orotic aciduria is:
1) Adenosine
2) Guanosine
3) Thymidine
4) Uridine
Ans: 4
Ques # :92
Bence Jones protein in urine is detected by:
1) FIGLU test
2) Bradshaw's test
3) Hay's test
4) Rothera's test
Ans: 2
Ques # :93
Which type of solution is used to reduce the intracranial pressure?
1) Isotonic
2) Hypotonic
3) Hypertonic
4) Colloidal
Ans: 3
Ques # :94
Choline plays role in all except
1) Transmethylation
2) Nerve transmission
3) Blood coagulation
4) Lipotropic factor
Ans: 3
Ques # :95
In-vitro techniques used for the production of monoclonal antibodies is :
1) Recombinant DNA technology
2) Hybridoma technology
3) Polymerase chain reaction
4) ELISA
Ans: 2
Ques # :96
The most damaging radiation to the tissues are
1) Alpha rays
2) Beta rays
3) Gamma rays
4) Radiowaves
Ans: 1
Ques # :97
Disease related to diffective repair of DNA damage are all except
1) Xeroderma pigmentosum
2) Prion Disease
3) Cockayne syndrome
4) Ataxia telangiectasia
Ans: 2
Ques # :98
Carnitine is sythesized from amino acids
1) Lysine and cysteine
2) Lysine and arginine
3) Lysine and glycine
4) Lysine and Methionine
Ans: 4
99:-The size of Okazaki segments synthesized on lagging strand of bacterial DNA is approximately
A:-100 - 200 nucleotides
B:-100 - 200 base pairs
C:-1000 - 2000 nucleotides
D:-1000 - 2000 base pairs
Ans: C
100:-Galactosemia
A:-is a genetic deficiency of a uridylyltransferase that exchanges galactose 1-phosphate for glucose on UDP-glucose
B:-results from a deficiency of an epimerase
C:-is not apparent at birth but symptoms develop in later life
D:-is an inability to form galactose 1-phosphate
Ans: A
The first gene therapy in human was carried out by French Anderson in:
1) 1990
2) 1970
3) 1980
4) 1995
Ans: 1
Ques # :32
Aging cell will release iron with the help of a copper containing protein called
1) Hepcidin
2) Hephaestin
3) Hemosiderin
4) Hemopexin
Ans: 2
Ques # :33
Which monosaccharide causes sequestering of phosphate in cell
1) Glucose
2) Fructose
3) Ribose
4) Galactose
Ans: 2
Ques # :34
Amino acid with thio-ether group is
1) Cysteine
2) Histidine
3) Methionine
4) Threonine
Ans: 3
Ques # :35
Hydrolysis of ATP into ADP and Pi liberates energy of
1) 3.4 kcal/mol
2) 5.0 kcal/mol
3) 7.3 kcal/mol
4) 10.3 kcal/mol
Ans: 3
Ques # :36
Enzyme used as a therapeutic agent
1) Asparaginase
2) Gamma glutamyltransferase
3) Taq Polymerase
4) Restriction endonuclease
Ans: 1
Ques # :37
Which molecular form of vitamine- A has role in skin disease
1) Beta-carotene
2) Retinol
3) Retinoic acid
4) Retinal
Ans: 3
Ques # :38
Peptide linkage is present in which vitamine structure
1) Riboflavin
2) Pantothenic acid
3) Biotin
4) Niacin
Ans: 2
Ques # :39
Iodide pump in thyroid gland functions by:
1) Primary active transport system
2) Carrier type transport system
3) Vesicular type transport system`
4) Secondary active transport system
Ans: 4
Ques # :40
Detoxification of methanol and ethanol is done through
1) Hydrolysis
2) Oxidation
3) Reduction
4) Conjugation
Ans: 2
Ques # :41
Major cause of metabolic acidosis is:
1) Overdose of narcotics
2) Potassium deficiency
3) Hepatic failure
4) Diabetic ketoacidosis
Ans: 4
Ques # :42
Specific Dynamic Action(SDA) is highest for
1) Carbohydrates
2) Lipids
3) Proteins
4) Vitamins
Ans: 3
Ques # :43
Dietary fibers have beneficial effects in:
1) Cancers
2) Diabetes mellitus
3) Obesity
4) All of them
Ans: 4
Ques # :44
Trace metal used for prevention of peroxidation of lipids
1) Selenium
2) Chromium
3) Cobalt
4) Molybdenum
Ans: 1
Ques # :45
Disease associated with impaired synthesis of collagen protein
1) Scurvy
2) Alport syndrome
3) Ehlers-Danlos syndrome
4) all of them
Ans: 4
Ques # :46
Pauly's test is for the presence of
1) Histidine
2) Arginine
3) Tyrosine
4) Tryptophan
Ans: 1
Ques # :47
Allopurinol is structural analog of:
1) Hypoxanthine
2) Xanthine
3) Uric acid
4) Alloxanthine
Ans: 1
Ques # :48
In myocardial infaction serum level of the which LDH enzyme is elevated :
1) LDH-1
2) LDH-3
3) LDH-4
4) LDH-5
Ans: 1
Ques # :49
Hydroxylatiom of 25-hydroxycholecalciferol by 1-α hydroxylase occurs in :
1) Skin
2) Liver
3) Kidneys
4) Intestine
Ans: 3
Ques # :50
Eating excess raw eggs causes deficiency of
1) Riboflavin
2) Niacin
3) Folic acid
4) Biotin
Ans: 4
Ques # :51
A salivary protein Gusten contains
1) Zinc
2) Manganese
3) Selenium
4) Chromium
Ans: 1
Ques # :52
The tubular maximum for glucose (TmG) is
1) .350 mg/min
2) .350 mg/dl
3) .350 mg/ml
4) .350 ml/min
Ans: 1
Ques # :53
Porphyria inherited as autosomal recessive disorder :
1) Erythropoietic protoporphyria
2) Congenital erythropoietic porphyria
3) Acute intermittent porphyria
4) Variegate porphyria
Ans: 2
Ques # :54
Achlorhydria condition is seen in:
1) Zollinger-Ellison syndrome
2) Gastric Carcinoma
3) Pernicious anemia
4) Duodenal ulcer
Ans: 3
Ques # :55
Water excretion by kidneys is tightly regulated by:
1) Aldosterone
2) Epinephrine
3) Oxytocin
4) Vasopressin
Ans: 4
Ques # :56
In replication the function of following enzyme is comparable with Zip opener
1) DNA Liagase
2) DNA Helicase
3) DNA Gyrase
4) DNA topoisomerase
Ans: 2
Ques # :57
In translation, the number of high energy phosphate bonds used for incorporating a single
amino acid is
1) 3
2) 4
3) 5
4) 6
Ans: 2
Ques # :58
Oncogenic virus which is not a DNA virus
1) Adenovirus
2) Papovirus
3) Retro virus
4) Herpes virus
Ans: 3
Ques # :59
Seperation of molecules in electrophoresis depends on
1) Size
2) Charge
3) Magnitude of current
4) All of them
Ans: 4
Ques # :60
Prostanoids includes all EXCEPT
1) Prostacyclins
2) Lipoxins
3) Thromboxanes
4) Prostaglandin
Ans: 2
Ques # :61
Triple Helix structure is seen in
1) Collagen
2) Silk
3) Myoglobin
4) Hemoglobin
Ans: 1
Ques # :62
Trehalose is :
1) Non reducing disaccharide
2) Major sugar of insect hemolymph
3) Hydrolyzed into two-α glucose molecule
4) All of them
Ans: 4
Ques # :63
The Phase-I biotransformation includes all reactions except
1) Oxidation
2) Conjugation
3) Hydrolysis
4) Reduction
Ans: 2
Ques # :64
Release of which hormone from endronic gland is facilitated by calcium ions
1) Insulin
2) PTH
3) Calcitonin
4) All of them
Ans: 4
Ques # :65
Hypoxia Occuring in high altitudes causes
1) Metabolic acidosis
2) Respiratory alkalosis
3) Metabolic acidosis
4) Respiratory acidosis
Ans: 2
Ques # :66
Increased urinary excretion of uroblinogen is observed in
1) Hemolytic jaundice
2) Hepatic jaundice
3) Obstructive jaundice
4) All of them
Ans: 1
Ques # :67
Kidneys regulate electrolyte balance through
1) Aldosterone
2) Atrial natriuretic factor
3) Bradykinin and Kallidin
4) All of them
Ans: 4
Ques # :68
Clinical manifestation of Kwashiorkor includes EXCEPT
1) Oedema
2) Diarrhoea
3) Moon face
4) Emaciation
Ans: 4
Ques # :69
Minamata disease is due to toxicity of:
1) Mercury
2) Arsenic
3) Cadmium
4) Lead
Ans: 1
Ques # :70
Which immunoglobulin mediates primary immune response
1) Ig G
2) Ig A
3) Ig M
4) Ig D
Ans: 3
Ques # :71
High degree of fidelity during replication is maintained by:
1) DNA topoisomerase
2) DNA Helicase
3) DNA polymerase
4) DNA ligase
Ans: 3
Ques # :72
The promotors elements of transcription are present on:
1) Template strand
2) Coding strand
3) RNA polymerase
4) hn-RNA
Ans: 2
Ques # :73
Which one is antioncogene:
1) c-ras
2) v-ras
3) c-myc
4) RB1
Ans: 4
Ques # :74
All the following are glycoproteins EXCEPT:
1) TSH
2) Globosides
3) Alkaline Phosphotase
4) Lectins
Ans: 2
Ques # :75
The property of surface tension is applied in all processes except:
1) Digestion and Absorption of fats
2) Exchange of gases in lungs
3) Oedema due to hypoalbuminemia
4) Detections of bile salts in urine
Ans: 3
Ques # :76
One amino acid may have more than one codon. The property of genetic code is :
1) Degeneracy
2) Specificity
3) Universality
4) Unambiguity
Ans: 1
Ques # :77
Tumour marker associated with carcinoma thyroid gland:
1) Alphafetoprotein
2) CA-125
3) Calcitonin
4) Neuron specific enolase
Ans: 3
Ques # :78
Hormone that causes obesity
1) Laptin
2) Ghrelin
3) Adiponectin
4) PYY-36
Ans: 2
Ques # :79
Compound acting as inhibitor of complex-I of electron transport chain
1) Malonate
2) Amobarbital
3) Antimycin-A
4) Cyanide
Ans: 2
Ques # :80
Level of structural organization preserved during denaturation of proteins:
1) Primary
2) Secondary
3) Tertiary
4) Quaternary
Ans: 1
Ques # :81
Cardiolipin is associated with
1) Barth syndrome
2) Parkinson's disease
3) Tangier's disease
4) All of them
Ans: 4
Ques # :82
The nitrogen atoms in urea originates from:
1) Ammonia and alanine
2) Ammonia and glutamine
3) Glutamate and aspartate
4) Alanine and aspartate
Ans: 3
Ques # :83
Barlows disease is due to deficiency of :
1) Vitamin-A
2) Vitamin-C
3) Vitamin-K
4) Vitamin-B3
Ans: 2
Ques # :84
Argentaffinomas in malignant carcinoid are usually seen in cells of :
1) Brain
2) Gastrointestinal tract
3) Heart
4) Lungs
Ans: 2
Ques # :85
The compound providing color to stool is :
1) Bilirubin
2) Stercobilinogen
3) Stercobilin
4) Urobilinogen
Ans: 3
Ques # :86
the amino acid required for the synthesis of Nitric oxide
1) Alanine
2) Argininoosuccinate
3) Tryptophan
4) Arginine
Ans: 4
Ques # :87
Regulatory gene in Lac-operon is:
1) Lac-I
2) Lac-Z
3) Lac-Y
4) Lac-A
Ans: 1
Ques # :88
Inhibition of glycolysis by oxygen is known as:
1) Krebs effect
2) Hills effect
3) Cori's effect
4) Pasteur effect
Ans: 4
Ques # :89
The hormone that stimulates mammotropic and lactogenic action is
1) TSH
2) Prolactin
3) LH
4) Progestrone
Ans: 2
Ques # :90
The Biochemical marker for the assessment of lipid peroxidation is:
1) Hydroperoxide
2) Reactive hydrogen species
3) Malondialdehyde
4) Ceruloplasmin
Ans: 3
Ques # :91
The nucleotide used in the treatment of orotic aciduria is:
1) Adenosine
2) Guanosine
3) Thymidine
4) Uridine
Ans: 4
Ques # :92
Bence Jones protein in urine is detected by:
1) FIGLU test
2) Bradshaw's test
3) Hay's test
4) Rothera's test
Ans: 2
Ques # :93
Which type of solution is used to reduce the intracranial pressure?
1) Isotonic
2) Hypotonic
3) Hypertonic
4) Colloidal
Ans: 3
Ques # :94
Choline plays role in all except
1) Transmethylation
2) Nerve transmission
3) Blood coagulation
4) Lipotropic factor
Ans: 3
Ques # :95
In-vitro techniques used for the production of monoclonal antibodies is :
1) Recombinant DNA technology
2) Hybridoma technology
3) Polymerase chain reaction
4) ELISA
Ans: 2
Ques # :96
The most damaging radiation to the tissues are
1) Alpha rays
2) Beta rays
3) Gamma rays
4) Radiowaves
Ans: 1
Ques # :97
Disease related to diffective repair of DNA damage are all except
1) Xeroderma pigmentosum
2) Prion Disease
3) Cockayne syndrome
4) Ataxia telangiectasia
Ans: 2
Ques # :98
Carnitine is sythesized from amino acids
1) Lysine and cysteine
2) Lysine and arginine
3) Lysine and glycine
4) Lysine and Methionine
Ans: 4
99:-The size of Okazaki segments synthesized on lagging strand of bacterial DNA is approximately
A:-100 - 200 nucleotides
B:-100 - 200 base pairs
C:-1000 - 2000 nucleotides
D:-1000 - 2000 base pairs
Ans: C
100:-Galactosemia
A:-is a genetic deficiency of a uridylyltransferase that exchanges galactose 1-phosphate for glucose on UDP-glucose
B:-results from a deficiency of an epimerase
C:-is not apparent at birth but symptoms develop in later life
D:-is an inability to form galactose 1-phosphate
Ans: A