BIOCHEMISTRY- PAGE 2
BIOCHEMISTRY- MEDICAL DEPARTMENT MCQs
1. Microsatelite sequence is
1) Small satelite 2) Extra Chromosomal DNA
3) Short sequence (2-5) repeat DNA 4) Looped DNA
Ans: 3
2. If starvation exceeds 7 day, the major nutritional supply of the brain comes from
1) Fatty acids 2) Ketone Bodies
3) Protein breakdown 4) Carbohydrate breakdown
Ans: 2
3. DNA estimation can be done by:
1) Spirometer 2) Spectrophotometer 3) Ph meter 4) Sphygnometer
Ans: 2
4. FIGLU is a metabolite of
1) Revoflavin 2) Thyrosine 3) Histidine 4) Alamine
Ans: 3
5. The enzymes used in polymerase chain reaction :
1) Thermostable enzymes 2) Enzymes stabiliser 3) Inorganic ion 4) Inorganic metal
Ans: 1
6. All of the following enzymes are involved in oxidation reduction reaction except
1) Dehydrogenase 2) Hydrolases 3) Oxygenase 4) Peroxidases
Ans: 2
7. Which coenzyme is resposible for carboxylation reaction
1) Biotin 2) FAD 3) NADH 4) TPD
Ans: 1
8. Which is true about Phage DNA
1) Antibiotic susceptibility 2) Restriction enzyme sites 3) Hexagonal DNA 4) Carrier short segment of DNA
Ans: 2
9. Ketone body formation without glycosuria seen in :
1) Diabetes Mellitus 2) Diabetes Insipidus 3) Prolonged starvation 4) Obesity
Ans: 3
10. Western Blot technique is done for
1) Mitochondrial RNA 2) DNA 3) rRNA 4) Proteins
Ans: 4
11. Reverse transcriptase is
1) DNA dependent RNA polymerase 2) RNA dependent DNA polymerase
3) DNA dependent DNA polymerase 4) RNA dependent RNA polymerase
Ans: 2
12. How many ATP's are formed in case of β oxidation of stearic acid :
1) 7 2) 18 3) 56 4) 147
Ans: 4
13. Study of structure and product of gene is
1) Genomics
2) Inoteomics
3) Bioinformatics
4) Cytogenatics
Ans: 1
14. Bile acids are derived from
1) Fatty acids 2) Cholesterol 3) Bilirubin 4) Proteins
Ans: 2
15. Zinc is cofactor for
1) Alcohol dehydrogenase 2) Pyruvate carboxylase 3) Hexokinase 4) Alphaketo glutarate dehydrogenase
Ans: 1
16. Which biochemical pathway does not occur in the mitochondria
1) Kreb's cycle 2) Urea cycle 3) gluconeogenase 4) Fatty acid synthesis
Ans: 4
17. Which of the following is increased in Lipoprotein lipase deficiency
1) VLDL 2) LDL 3) HDL 4) Chylomicron
Ans: 4
18. Which vein in anticubital fossa is preferred site for collection of venous blood in adult
1) Brachial 2) Radial 3) Median cubital 4) Cubital
Ans: 3
19. Name the anticogulant among following
1) Fumarate 2) Idoacetate 3) Oxalates 4) Arsenic
Ans: 3
20. Heprin is an anticoagulant which accelerates action of :
1) Prothrombin 2) Antithrombin III 3) Factor 2 4) Factor 4
Ans: 2
21. Normal level of serum urea is :
1) 40-80 mg/dl 2) 20-30 mg/dl 3) 20-45 mg/dl 4) 80-100 mg/dl
Ans: 3
22. Normal level of HbA1C is
1) 2-3% 2) 4-9% 3) 5-6% 4) 1-2%
Ans: 3
23. In preheptic jaundice which type of bilirubin is raised
1) Direct 2) Conjugated 3) Indirect 4) Bile salt
Ans: 3
24. Clay colored stool is seen in which jaundice
1) Prehepatic 2) Hemolytic 3) Posthepatic 4) Hepatic
Ans: 3
25. In hemolyte jaundice, urine shows
1) Absence of bile pigments and presence of urobilinogen
2) Absence of bile pigments and urobilinogen
3) Presence of bile pigments and urobilinogen
4) Presence of bile pigments and absence of urobilinogen
Ans: 1
26. In Obstructive jaundice urine shows
1) Presence of bile pigments and absence of urobilinogen
2) Presence of bile pigments and urobilinogen
3) Absence of bile pigments and urobilinogen
4) Absence of bile pigments and presence of urobilinogen
Ans: 1
27. Prothrombin is synthesised in
1) Liver 2) Kidneys 3) Erythyrocytes 4) Spleen
Ans: 1
28. Hematuria can occur in
1) Stone in urinary tract 2) Mismatched blood transfusion 3) Ketosis 4) Yellow fever
Ans: 1
29. Standard urea clearance in normal subjects is
1) 54 ml/min 2) 64 ml/min 3) 74 ml/min
4) 104 ml/min
Ans: 1
30. Sweat chloride are increased in
1) Acute pancreatilis 2) Cystic fibrosis 3) Pacreatic cancer 4) Acute glomerulonephritis
Ans: 2
31. Maximum rise in serum amylase occurs in
1) Infective hepatittis 2) Acute pancreatilis 3) Pacreatic cancer 4) Acute parotities
Ans: 2
32. BMR is increased in
1) cretinism 2) Hyperthyrodism 3) Endemic goitre 4) Myxoedema
Ans: 2
33. N-acetylglucosamine is present in
1) Chondroitin sulphate 2) hyaluronic acid 3) Heparin 4) Inulin
Ans: 2
34. Predominant form of glucose in solution is
1) glucofuranose 2) glucopyranose 3) Acyclic form 4) Hydrated acyclic form
Ans: 2
35. Lipid content of chylomicron is about
1) 70% 2) 99% 3) 80% 4) 30%
Ans: 2
36. Pyruvate kinase is inhibited by
1) Citrate 2) Enolpyruvate 3) Alanine 4) Lactale
Ans: 3
37. Unique by product of glycolysis in erythrocytes is
1) Isocitrate 2) 1,3 biphosphoglycerate 3) 2,3 biphosphoglycerate 4) Lactate
Ans: 3
38. Coenzyme of transketolase is
1) FAD 2) NAD 3) Thiamine pyrophosphate 4) NADP
Ans: 3
39. Glucose is the only source of energy for
1) Kidney 2) Myocardium 3) RBC 4) Spleen
Ans: 3
40. Increased activity of PRAP synthetase can cause
1) Diabetes mellitus 2) Immunodeficiency 3) Diabetes insipidus 4) Gout
Ans: 4
41. In mycardia infarction last serum enzyme to return to normal is
1) GOT 2) creatine kinase 3) GPT 4) LDH
Ans: 4
42. Niacin contains
1) Amide group 2) Carboxyl group 3) Sulfhydryl group 4) Hydroxyl group
Ans: 2
43. NADP is required as a coenzyme in
1) Citric acid cycle 2) HMP shunt 3) Gluconeogenasis 4) Glycolysis
Ans: 2
44. Anti-egg white egg injury factor is
1) Niacin 2) Biotin 3) Pyridoxin 4) Riboflavin
Ans: 2
45.Human beings cannot synthesise ascorbic acid because they lack
1) L-gulonate dehydrogenase
2) L-gulunolactone oxidase
3) xylylose reduclase
4) HMG Co A reduclase
Ans: 2
46. Vitamin which can be synthesised by human being:
1) Niacin 2) Riboflavin 3) Thiamin 4) Folic acid
Ans: 1
47. Rhodopsin contains opsin and
1) 11-cis-retinal 2) 11-trans-retinol 3) all-cis-retinol 4) all-trans-retinal
Ans: 1
48. Water soluble form of vitamin K is
1) Menadione 2) Phylloquinone 3) Menaquinone 4) Tocopherol
Ans: 1
49. Iron is stroed in form of
1) Ferritin and haemosiderin
2) Ferritin and transferin
3) Hemoglobin and myoglobin
4) tranferrin and Haemosiderin
Ans: 1
50. Copper deficiency can cause :
1) Microcytic anaemia 2) Polycythemia 3) Leukocytopenia 4) Thrombocytopenia
Ans: 1
1) Small satelite 2) Extra Chromosomal DNA
3) Short sequence (2-5) repeat DNA 4) Looped DNA
Ans: 3
2. If starvation exceeds 7 day, the major nutritional supply of the brain comes from
1) Fatty acids 2) Ketone Bodies
3) Protein breakdown 4) Carbohydrate breakdown
Ans: 2
3. DNA estimation can be done by:
1) Spirometer 2) Spectrophotometer 3) Ph meter 4) Sphygnometer
Ans: 2
4. FIGLU is a metabolite of
1) Revoflavin 2) Thyrosine 3) Histidine 4) Alamine
Ans: 3
5. The enzymes used in polymerase chain reaction :
1) Thermostable enzymes 2) Enzymes stabiliser 3) Inorganic ion 4) Inorganic metal
Ans: 1
6. All of the following enzymes are involved in oxidation reduction reaction except
1) Dehydrogenase 2) Hydrolases 3) Oxygenase 4) Peroxidases
Ans: 2
7. Which coenzyme is resposible for carboxylation reaction
1) Biotin 2) FAD 3) NADH 4) TPD
Ans: 1
8. Which is true about Phage DNA
1) Antibiotic susceptibility 2) Restriction enzyme sites 3) Hexagonal DNA 4) Carrier short segment of DNA
Ans: 2
9. Ketone body formation without glycosuria seen in :
1) Diabetes Mellitus 2) Diabetes Insipidus 3) Prolonged starvation 4) Obesity
Ans: 3
10. Western Blot technique is done for
1) Mitochondrial RNA 2) DNA 3) rRNA 4) Proteins
Ans: 4
11. Reverse transcriptase is
1) DNA dependent RNA polymerase 2) RNA dependent DNA polymerase
3) DNA dependent DNA polymerase 4) RNA dependent RNA polymerase
Ans: 2
12. How many ATP's are formed in case of β oxidation of stearic acid :
1) 7 2) 18 3) 56 4) 147
Ans: 4
13. Study of structure and product of gene is
1) Genomics
2) Inoteomics
3) Bioinformatics
4) Cytogenatics
Ans: 1
14. Bile acids are derived from
1) Fatty acids 2) Cholesterol 3) Bilirubin 4) Proteins
Ans: 2
15. Zinc is cofactor for
1) Alcohol dehydrogenase 2) Pyruvate carboxylase 3) Hexokinase 4) Alphaketo glutarate dehydrogenase
Ans: 1
16. Which biochemical pathway does not occur in the mitochondria
1) Kreb's cycle 2) Urea cycle 3) gluconeogenase 4) Fatty acid synthesis
Ans: 4
17. Which of the following is increased in Lipoprotein lipase deficiency
1) VLDL 2) LDL 3) HDL 4) Chylomicron
Ans: 4
18. Which vein in anticubital fossa is preferred site for collection of venous blood in adult
1) Brachial 2) Radial 3) Median cubital 4) Cubital
Ans: 3
19. Name the anticogulant among following
1) Fumarate 2) Idoacetate 3) Oxalates 4) Arsenic
Ans: 3
20. Heprin is an anticoagulant which accelerates action of :
1) Prothrombin 2) Antithrombin III 3) Factor 2 4) Factor 4
Ans: 2
21. Normal level of serum urea is :
1) 40-80 mg/dl 2) 20-30 mg/dl 3) 20-45 mg/dl 4) 80-100 mg/dl
Ans: 3
22. Normal level of HbA1C is
1) 2-3% 2) 4-9% 3) 5-6% 4) 1-2%
Ans: 3
23. In preheptic jaundice which type of bilirubin is raised
1) Direct 2) Conjugated 3) Indirect 4) Bile salt
Ans: 3
24. Clay colored stool is seen in which jaundice
1) Prehepatic 2) Hemolytic 3) Posthepatic 4) Hepatic
Ans: 3
25. In hemolyte jaundice, urine shows
1) Absence of bile pigments and presence of urobilinogen
2) Absence of bile pigments and urobilinogen
3) Presence of bile pigments and urobilinogen
4) Presence of bile pigments and absence of urobilinogen
Ans: 1
26. In Obstructive jaundice urine shows
1) Presence of bile pigments and absence of urobilinogen
2) Presence of bile pigments and urobilinogen
3) Absence of bile pigments and urobilinogen
4) Absence of bile pigments and presence of urobilinogen
Ans: 1
27. Prothrombin is synthesised in
1) Liver 2) Kidneys 3) Erythyrocytes 4) Spleen
Ans: 1
28. Hematuria can occur in
1) Stone in urinary tract 2) Mismatched blood transfusion 3) Ketosis 4) Yellow fever
Ans: 1
29. Standard urea clearance in normal subjects is
1) 54 ml/min 2) 64 ml/min 3) 74 ml/min
4) 104 ml/min
Ans: 1
30. Sweat chloride are increased in
1) Acute pancreatilis 2) Cystic fibrosis 3) Pacreatic cancer 4) Acute glomerulonephritis
Ans: 2
31. Maximum rise in serum amylase occurs in
1) Infective hepatittis 2) Acute pancreatilis 3) Pacreatic cancer 4) Acute parotities
Ans: 2
32. BMR is increased in
1) cretinism 2) Hyperthyrodism 3) Endemic goitre 4) Myxoedema
Ans: 2
33. N-acetylglucosamine is present in
1) Chondroitin sulphate 2) hyaluronic acid 3) Heparin 4) Inulin
Ans: 2
34. Predominant form of glucose in solution is
1) glucofuranose 2) glucopyranose 3) Acyclic form 4) Hydrated acyclic form
Ans: 2
35. Lipid content of chylomicron is about
1) 70% 2) 99% 3) 80% 4) 30%
Ans: 2
36. Pyruvate kinase is inhibited by
1) Citrate 2) Enolpyruvate 3) Alanine 4) Lactale
Ans: 3
37. Unique by product of glycolysis in erythrocytes is
1) Isocitrate 2) 1,3 biphosphoglycerate 3) 2,3 biphosphoglycerate 4) Lactate
Ans: 3
38. Coenzyme of transketolase is
1) FAD 2) NAD 3) Thiamine pyrophosphate 4) NADP
Ans: 3
39. Glucose is the only source of energy for
1) Kidney 2) Myocardium 3) RBC 4) Spleen
Ans: 3
40. Increased activity of PRAP synthetase can cause
1) Diabetes mellitus 2) Immunodeficiency 3) Diabetes insipidus 4) Gout
Ans: 4
41. In mycardia infarction last serum enzyme to return to normal is
1) GOT 2) creatine kinase 3) GPT 4) LDH
Ans: 4
42. Niacin contains
1) Amide group 2) Carboxyl group 3) Sulfhydryl group 4) Hydroxyl group
Ans: 2
43. NADP is required as a coenzyme in
1) Citric acid cycle 2) HMP shunt 3) Gluconeogenasis 4) Glycolysis
Ans: 2
44. Anti-egg white egg injury factor is
1) Niacin 2) Biotin 3) Pyridoxin 4) Riboflavin
Ans: 2
45.Human beings cannot synthesise ascorbic acid because they lack
1) L-gulonate dehydrogenase
2) L-gulunolactone oxidase
3) xylylose reduclase
4) HMG Co A reduclase
Ans: 2
46. Vitamin which can be synthesised by human being:
1) Niacin 2) Riboflavin 3) Thiamin 4) Folic acid
Ans: 1
47. Rhodopsin contains opsin and
1) 11-cis-retinal 2) 11-trans-retinol 3) all-cis-retinol 4) all-trans-retinal
Ans: 1
48. Water soluble form of vitamin K is
1) Menadione 2) Phylloquinone 3) Menaquinone 4) Tocopherol
Ans: 1
49. Iron is stroed in form of
1) Ferritin and haemosiderin
2) Ferritin and transferin
3) Hemoglobin and myoglobin
4) tranferrin and Haemosiderin
Ans: 1
50. Copper deficiency can cause :
1) Microcytic anaemia 2) Polycythemia 3) Leukocytopenia 4) Thrombocytopenia
Ans: 1
51. Hypogonadism can occur in deficiency of
1) Zinc 2) Chromium 3) Copper 4) Magnesium
Ans: 1
52. Trace element having antoxident function is
1) Selenium 2) Chromium 3) Aluminium 4) Cobalt
Ans: 1
53. Acrodermitatitis enteropathia can lead to deficiency of :
1) Copper 2) Phophorus 3) Calcium 4) Zinc
Ans: 4
54. Intracellular compartment contains (of the total body water)
1) 50% 2) 60% 3) 80% 4) 70%
Ans: 4
55. Highest concentration of proteins is present in
1) Interstitial fluid 2) Transcellular fluid 3) Plasma 4) Intracellular Fluid
Ans: 4
56. An amino acid required for porphyrin synthesis is
1) Serine 2) Histidine 3) Proline 4) Glycine
Ans: 4
57. In obstructive jaundice , faecal urobilinogon is
1) Increased 2) Absent 3) Decreased 4) Normal
Ans: 2
58. Protein content of egg is about
1) 10% 2) 15% 3) 13% 4) 25%
Ans: 3
59. Fat content of pulses is about
1) 10% 2) 15% 3) 20% 4) 5%
Ans: 4
60. Egg is poor in
1) Protein 2) Avidin 3) Carbohydrates 4) Essential amino acid
Ans: 3
61. G-proteins act as
1) Signal transducers
2) Hormone receptors
3) Second messengers
4) Hormone carriers
Ans: 1
62. Posterior pituitary glands secretes
1) Serotonin 2) Oxytocin 3) Catecholomines 4) Follicle stimulating hormone
Ans: 2
63. Nonapeptide among the following is:
1) Insulin 2) Antidiuretic hormone 3) ACTH 4) Thyrotropin releasing hormone
Ans: 2
64. ACTH is a polypeptide made up of
1) 26 amino acid 2) 64 amino acid 3) 39 amino acid 4) 92 amino acid
Ans: 3
65. In thyroxine , tyrosine residues are iodinated at positions
1) 2 & 4 2) 4 & 6 3) 3 & 5 4) 1 & 3
Ans: 3
66.The most abundant T cells are
1) Helper T cells 2) Suppressor T cells 3) Cytotoxic T cells 4) Memory T cells
Ans: 1
67. The human insulin gene is located on the short arm of chromosome No :
1) 7
2) 11
3) 16
4) 24
Ans: 2
68. Tendon is composed almost exclusively of :
1) Mucopolysaccharides 2) Prostaglandins 3) Collagen 4) Phospholipids
Ans: 3
69. Cushing's syndrome is caused due to the excessive secretion of hormone :
1) Glucocorticoids 2) Androgens 3) Catecholamines 4) ACTH
Ans: 1
70. Ubiquinone is known as :
1) Coenzyme A 2) Coenzyme Q 3) Plastoquinone 4) none of the above
Ans: 2
71. Tripeptide glutathione is made up of one of the following combination of three amino acids :
1) Glycine, cysteine and glutamic acid 2) Cysteine, alanine and serine
3) Proline, alanine and glycine 4) Threonine, glycine and cystine
Ans: 1
72. Rennin is also called as :
1) Chymosin 2) Trypsin 3) Chymotrypsin 4) Carboxypeptidase
Ans: 1
73. In childhood, an idiopathic hypoglycaemia due to the sensitivity of one of the following amino acids has been reported :
1) Leucine 2) Alanine 3) Glycine 4) Cysteine
Ans: 1
74. Disease associated with HLA gene is :
1) Myasthenia gravis 2) Peptic ulcer 3) Pulmonary tuberculosis 4) Jaundice
Ans: 1
75. Wernicke - Korsakoff syndrome is found in :
1) Chronic alcoholic cases 2) Chronic banana eaters 3) Chronic smokers 4) Chronic cancer patients
Ans: 1
76. Human bile contains:
1) Chenodeoxycholic acid 2) 7- dehydrocholesterol 3) Coprostanol 4) Dihydrocholesterol
Ans: 1
77. Peri-mitochondrial space consists of the enzyme:
1) Adenylate cyclase 2) Pyruvate dehydrogenase complex 3) Citrate synthetase 4) Monoamine Oxidase
Ans: 1
78. Matrix of mitochondria consists of the enzyme(s) :
1) Enzymes of TCA cycle 2) Enzymes of Glycolytic pathway 3) Nucleoside diphosphokinase 4) HMG CoA synthetase
Ans: 1
79. Dextrans are highly branched homopolymers of :
1) Glucose units 2) Fructose units. 3) Mannose units 4) Galactose units
Ans: 1
80. Pancreatic amylase is :
1) alpha amylase 2) beta amylase 3) gamma amylase 4) delta amylase
Ans: 1
81. Iodine number of butter is :
1) 08 2) 18 3) 28 4) 38
Ans: 3
82. Insulin receptor is a transmembrane:
1) Heteromonomer 2) Heterodimer 3) Heterotrimer 4) Heterotetramer
Ans: 4
83. Kussmaul breathing is found in :
1) Diabetic coma 2) Severe Heart Attack 3) Malignancy (Cancer) 4) Nephrosis
Ans: 1
84. Which compound inhibits the activity of enzyme aconitase in TCA cycle
1) Arsenite 2) Malonate 3) AMP 4) Fluoroacetate
Ans: 4
85. Enzyme pyruvate carboxylase converts pyruvate to :
1) Lactic acid 2) Malate 3) Fumarate 4) Oxaloacetate
Ans: 4
86. Which of the following reagents would be most useful in determining the N-terminal amino acid of a polypeptide
1) Trypsin 2) Carboxypeptidase 3) Phenylisothiocyanate 4) Cyanogens bromide
Ans: 3
87. An uncoupler of oxidative phosphorylation such as dinitrophenol :
1) Inhibits electron transport and ATP synthesis
2) Allow electron transport to proceed without ATP systhesis.
3) Inhibits electron transport without impairment of ATP synthesis
4) Specifically inhibits cyt b
Ans: 2
88. Which one of the following reactions in unique to gluconeogenesis ?
1) Lactate → pyruvate
2) Phosphoenolpyruvate → pyruvate
3) Oxaloacetate → phosphoenlpyruvate
4) Glucose 6-phosphate →fructose 6-phosphate
Ans: 3
89. Mucopolysaccharidoses are inherited storage diseases caused by :
1) An increased rate of synthesis of proteoglycans
2) The synthesis of polysaccharides with an altered structure
3) Defects in the degradation of proteoglycans
4) The synthesis of abnormally small amounts of protein cores
Ans: 3
90. In the absence of the bile selts, glycocholic and taurocholic acid, the intestinal absorption of all of the following would be impeded EXCEPT :
1) Riboflavin 2) Oleic acid 3) Cholesterol 4) Vitamin A
Ans: 1
91. A patient has a genetic defect resulting in a deficiency of lipoprotein lipase. After eating a meal containing a large amount of fat, one would expect to see a plasma elevation of :
1) Chylomicrons 2) VLDLs 3) LDLs 4) HDLs
Ans: 1
92. In which one of the following tissues is glucose transport into the cell enhanced by insulin?
1) Brain 2) Lens 3) Red blood cells 4) Adipose tissue
Ans: 4
93. Which one of the following is elevated in plasma during the absorptive period (compared to the post absorptive state)
1) Glucagon 2) Acetoacetate 3) Chylomicrons 4) Free fatty acids
Ans: 3
94. Zona glomerulosa secretes
1) Cortisol 2) Corticosterone 3) Mineralocorticoid 4) Testosterone
Ans: 3
95. Treatment by introducing enzyme into somatic cells by gene therapy is given in all of the following except :
1) Adenosine deaminase deficiency 2) Phenylketonuria 3) Cystic fibrosis 4) Familial hypercholesterolemia
Ans: 2
96. Storage form of iron is :
1) Ferritin 2) Hemoglobin 3) Protoporphyrin IX 4) Heme
Ans: 1
97. LDL-receptor was discovered by Nobel Laureate :
1) Goldstein 2) Linus Pauling 3) Lipman 4) Krbs, Sir Hans Adolf
Ans: 1
98. In 100 ml of blood having normal albumin concentration, the maximum quantity of bilirubin that can be bound to high affinity site of albumin is about :
1) 1 mg 2) 10 mg 3) 15 mg 4) 25 mg
Ans: 4
99. The following is a harmless condition :
1) Gilbert’s syndrome 2) Crigler- Najjar syndrome 3) Rotor syndrome 4) Dubin- Johnson syndrome
Ans: 1
100. Okazaki pieces are made up of :
1) RNA 2) DNA 3) RNA and DNA 4) RNA and Proteins
Ans: 3