BIOCHEMISTRY- MEDICAL DEPARTMENT- PAGE 4
BIOCHEMISTRY- MEDICAL DEPARTMENT MCQs
1:-Which of the following is NOT a serine protease?
A:-Trypsin B:-Thrombin C:-Carbonic anhydrase D:-Chymotrypsin
Ans: C
2:-Which is the best marker of ventricular dysfunction?
A:-CK-MB B:-Cardiac troponin I C:-Brain natriuretic peptide D:-Myoglobin
Ans: C
3:-Select the glucose transporter that is insulin dependent.
A:-GLUT 2 B:-GLUT 4 C:-GLUT 5 D:-SGLT 1
Ans: B
4:-Which of the following statement is FALSE regarding mitochondrial DNA?
A:-Majority of the mitochondrial proteins are coded by mitochondrial DNA
B:-Mitochondrial DNA have high mutation rate than nuclear DNA
C:-Mitochondrial cytopathies show a maternal non-mendelian inheritance
D:-Mitochondrial DNA shows heteroplasmy
Ans: A
5:-Regarding p53 all the statements are true EXCEPT
A:-Is a DNA binding transcription factor B:-Induces the genes that induce apoptosis
C:-Is the least mutated genes in human cancers D:-Is a tumor suppressor gene
Ans: C
6:-Regarding apoptosis, select the FALSE statement.
A:-Cytochrome c is an inducer of apoptosis B:-bcl-2 is an apoptosis protecting gene
C:-Caspase 3 is the initiator caspase of apoptosis D:-Ceramide is an important regulator of apoptosis
Ans: C
7:-Which one of the following is a chain breaking anti-oxidant?
A:-Catalase B:-Vitamin E C:-Glutathione peroxidase D:-Ethylenediaminetetraacetate
Ans: B
8:-Select the enzyme that is NOT present in the liver.
A:-HMG Co A lyase B:-HMG Co A synthase C:-Thiolase D:-Thiophorase
Ans: D
9:-Linoleic acid is considered to be a nutritionally essential fatty acid in humans BECAUSE
A:-It is an omega 3 fatty acid
B:-In humans double bond cannot be introduced at Δ`^6` position
C:-In humans double bond cannot be introduced at Δ`^9` position
D:-In humans double bond cannot be introduced at Δ`^12` position
Ans: D
10:-Regarding insulin which of the following statement is FALSE?
A:-Inhibits hormone sensitive lipase B:-Inhibits acetyl Co A carboxylase
C:-Activates glycerol phosphate acyl transferase D:-Activates pyruvate dehydrogenase
Ans: B
11:-Which one of the following is NOT a cause of fatty liver?
A:-Protein deficiency B:-Orotic acid deficiency C:-Pantothenic acid deficiency D:-Linoleic acid deficiency
Ans: B
12:-Niemann-Pick disease is due to the deficiency of
A:-Hexosaminidase A B:-Hexosaminidase A and B C:-Beta glucosidase D:-Sphingomyelinase
Ans: D
13:-All the following statements are true regarding water EXCEPT
A:-Water molecules form dipoles B:-The angle between two hydrogen atoms in water molecule is 105°
C:-Has low dielectric constant D:-Is an excellent nucleophile
Ans: C
14:-Which of the following can be a cause of Normal Anion Gap Metabolic Acidosis?
A:-Organic aciduria B:-Salicylate poisoning C:-Acetazolamide therapy D:-Lactic acidosis
Ans: C
15:-All the following statements regarding pKa are true EXCEPT
A:-At pKa the ratio of salt to acid in a buffer is 2:1 B:-At pKa the buffer has maximum buffering capacity
C:-pKa of an acid is the pH at which the acid is half ionized D:-Weak acids have high pKa
Ans: A
16:-Which one of the following test is used to detect CSF globulins?
A:-Heller's test B:-Pandy's test C:-Oliver's test D:-Pettenkoffer's test
Ans: B
17:-Of the following which hypotheses claims that there is an association between the predictor and outcome variables?
A:-Alternative hypotheses B:-Null hypotheses C:-Statistical hypotheses D:-Composite hypotheses
Ans: A
18:-If mean is 25 and standard deviation is 5, then coefficient of variation is
A:-5% B:-20% C:-25% D:-75%
Ans: B
19:-Which of the following is the best test based on the ROC curve?
A:-Area under the curve is more than 0.9 B:-Area under the curve is 0.5
C:-Area under the curve is less than 0.1 D:-Area under the curve is less than 0.01
Ans: A
20:-Which one of the following statements is NOT TRUE regarding telomerase?
A:-It's activity is increased in cancer B:-Loss of telomerase activity leads to aging
C:-It is a ribozyme D:-It has reverse transcriptase activity
Ans: C
21:-Assertion: Phenyl alanine is a ketogenic amino acid.
Reason : Catabolism of phenylalanine yields fumarate that enters into TCA cycle.
a) If both A and R are true and R is correct explanation of A
b) If both A and R are true but R is not the correct explanation of A
c) If R is true but A is false
d) If both A and R are false.
Ans: Both A and R are true but R is not the correct explanation of A
22:-Which one of the following molecular techniques is used to detect a specific RNA?
A:-Southern blot technique B:-Northern blot technique C:-Western blot technique D:-In situ hybridization
Ans: B
23:-Which one of the following features about genetic code is INCORRECT?
A:-Non-degenerate B:-Non-ambiguous C:-Non-overlapping D:-Continuous
Ans: A
24:-Which one of the following conditions results from defective alpha oxidation?
A:-Methyl malonic aciduria B:-Glutaric aciduria C:-Refsum's disease D:-Propionic acidemia
Ans: C
25:-Which one of the following amino acids is purely ketogenic?
A:-Leucine B:-Isoleucine C:-Lysine D:-Phenyl alanine
Ans: A
26:-All the following conditions show low serum AFP level EXCEPT
A:-Down syndrome B:-Anencephaly C:-Trisomy 18 D:-Turners syndrome
Ans: B
27:-All the following statements regarding glutathione are true EXCEPT
A:-It favours the absorption of neutral amino acids in the intestine B:-It inactivates insulin
C:-It is an atypical tripeptide D:-It plays an important role in free radical scavenging
Ans: B
28:-Which one of the following is NOT a post-transcriptional modification?
A:-5' capping B:-Poly-A tailing C:-Acetylation D:-Methylation
Ans: C
29:-Select the FALSE statement regarding phosphofructokinase 1.
A:-It is activated by AMP B:-Fructose 2,6 bisphosphate inhibits this enzyme
C:-During starvation the synthesis of this enzyme is repressed D:-Fructose 6 phosphate activates this enzyme
Ans: B
30:-All the following statements regarding pentose phosphate pathway is correct EXCEPT
A:-Glucose-6-phosphate dehydrogenase is the rate limiting enzyme of the pathway
B:-In RBCs it is the only source of NADPH for free radical scavenging
C:-No ATP is produced in this pathway
D:-Glucose-6-phosphate dehydrogenase is inhibited by insulin
Ans: D
31:-Which one of the following statements about glycogen metabolism is INCORRECT?
A:-Glucagon enhances glycogenolysis in muscle
B:-Epinephrine enhances glycogenolysis in liver and muscle
C:-Glycogenolysis in liver will lead to increase in blood glucose level
D:-Pyridoxal phosphate is essential for glycogenolysis in muscle
Ans: A
32:-Regarding pancreatic lipase the INCORRECT statement is
A:-It is a glycoprotein
B:-It's serum level is increased in renal insufficiency
C:-It has a specificity of 80-100% in diagnosing acute pancreatitis
D:-It's serum level increases within 8 to 12 hours and reaches a peak by 48 hours after an acute attack of pancreatitis
Ans: D
33:-Which is the soluble storage form of iron in tissues?
A:-Ferritin B:-Transferrin C:-Hemosiderin D:-Haptoglobin
Ans: A
34:-Black liver jaundice is seen in
A:-Dubin Johnson syndrome B:-Rotor syndrome
C:-Glibert's disease D:-Crigler-Najjar syndrome
Ans: A
35:-Select the neurotransmitter synthesized from tyrosine
A:-GABA B:-Melatonin C:-Dopamine D:-Serotonin
Ans: C
36:-Which of the following is used for staining DNA fragments in electrophoresis?
A:-Coomasssie Brilliant Blue B:-Nitrotetrazolium Blue C:-Silver Nitrate D:-Ethidium Bromide
Ans: D
37:-Which liver enzyme is best for detecting biliary obstruction?
A:-Alanine amino transferase B:-Alkaline phosphatase C:-Nucleotide phosphatase D:-Gamma glutamyl transferase
Ans: C
38:-Which of the following statement is NOT true regarding oncogenes?
A:-Mutation in one of the two alleles is sufficient to produce oncogenic effects
B:-Oncogenic effect is due to gain of function of a protein that stimulates cell growth and proliferation
C:-Mutations in oncogenes may be present in somatic or germ cells
D:-Usually do not show tissue preference with respect to the type of cancers in which they are found
Ans: C
39:-All the following are multienzyme complexes EXCEPT
A:-Pyruvate carboxylase B:-Alpha keto dehydrogenase C:-Acetyl Co A carboxylase D:-Pyruvate kinase
Ans: D
40:-Which of the following is an example for non-competitive inhibition?
A:-Allopurinol inhibits xanthine oxidase B:-Fluoride inhibits enolase
C:-5-fluorouracil inhibits thymidylate synthase D:-Lovastatin inhibits HMG Co A reductase
Ans: B
41:-Which one of the following diseases results from defective nucleotide excision repair mechanism?
A:-Xeroderma Pigmentosum B:-Hereditary Polyposis Colon Cancer
C:-Fanconi's Anemia D:-Bloom's Syndrome
Ans: A
42. In a membrane, carbohydrate moieties glycoproteins or glycolipids are
A. oriented towards outside B. placed towards inside
C. facing towards outside and inside D. randomly dispersed
Ans: A
43. The bilayered lipid bilayer ______ in nature
A. hydrophilic B. hydrophobic C. both D. the nature depends on the immediateenvironment
Ans: C
44. __________membrane contains the largest amount of proteins
A. red blood corpuscular membrane B. myelin sheath C. lyzosomalmembrane D. outer mitochondrial membrane
Ans:A
45. The distribution of inherent proteins in the membrane:
A. symmetrical B. asymmetrical C. random D. uniform
Ans: B
46. _________statement describes the role of a cell membrane?
A. free entry and exit of substances into or out of a cell B. controlled movement of substances across.
C. Block the entry of substances into the cell. D. Dismissess the exit of substances from the cell.
Ans: B
47. Generally, Non-essential amino acids are synthesized by _________ reactions.
a) Oxidative deamination b) Oxidative decarboxylation c) Transamination d) Non-oxidative deamination
Ans: C
48. Essential Aminoacids
a) are synthesized in the liver b) are only used in the synthesis of proteins
c) cannot be synthesized in the body d) are only catabolized to urea
Ans: C
49. Transamination involves
a) exchange of amino groups between a ketoacid and an aminoacid
b) addition of keto groups from a ketoacid to an aminoacid
c) transfer of amino groups from a ketoacid to an aminoacid
d) all the above
Ans: A
50. The coenzyme involved in transamination is
a) Pyridoxal phosphate b) Coenzyme Q c) Thiamine d) Pyridoxamine Phosphate
Ans: A
A:-Trypsin B:-Thrombin C:-Carbonic anhydrase D:-Chymotrypsin
Ans: C
2:-Which is the best marker of ventricular dysfunction?
A:-CK-MB B:-Cardiac troponin I C:-Brain natriuretic peptide D:-Myoglobin
Ans: C
3:-Select the glucose transporter that is insulin dependent.
A:-GLUT 2 B:-GLUT 4 C:-GLUT 5 D:-SGLT 1
Ans: B
4:-Which of the following statement is FALSE regarding mitochondrial DNA?
A:-Majority of the mitochondrial proteins are coded by mitochondrial DNA
B:-Mitochondrial DNA have high mutation rate than nuclear DNA
C:-Mitochondrial cytopathies show a maternal non-mendelian inheritance
D:-Mitochondrial DNA shows heteroplasmy
Ans: A
5:-Regarding p53 all the statements are true EXCEPT
A:-Is a DNA binding transcription factor B:-Induces the genes that induce apoptosis
C:-Is the least mutated genes in human cancers D:-Is a tumor suppressor gene
Ans: C
6:-Regarding apoptosis, select the FALSE statement.
A:-Cytochrome c is an inducer of apoptosis B:-bcl-2 is an apoptosis protecting gene
C:-Caspase 3 is the initiator caspase of apoptosis D:-Ceramide is an important regulator of apoptosis
Ans: C
7:-Which one of the following is a chain breaking anti-oxidant?
A:-Catalase B:-Vitamin E C:-Glutathione peroxidase D:-Ethylenediaminetetraacetate
Ans: B
8:-Select the enzyme that is NOT present in the liver.
A:-HMG Co A lyase B:-HMG Co A synthase C:-Thiolase D:-Thiophorase
Ans: D
9:-Linoleic acid is considered to be a nutritionally essential fatty acid in humans BECAUSE
A:-It is an omega 3 fatty acid
B:-In humans double bond cannot be introduced at Δ`^6` position
C:-In humans double bond cannot be introduced at Δ`^9` position
D:-In humans double bond cannot be introduced at Δ`^12` position
Ans: D
10:-Regarding insulin which of the following statement is FALSE?
A:-Inhibits hormone sensitive lipase B:-Inhibits acetyl Co A carboxylase
C:-Activates glycerol phosphate acyl transferase D:-Activates pyruvate dehydrogenase
Ans: B
11:-Which one of the following is NOT a cause of fatty liver?
A:-Protein deficiency B:-Orotic acid deficiency C:-Pantothenic acid deficiency D:-Linoleic acid deficiency
Ans: B
12:-Niemann-Pick disease is due to the deficiency of
A:-Hexosaminidase A B:-Hexosaminidase A and B C:-Beta glucosidase D:-Sphingomyelinase
Ans: D
13:-All the following statements are true regarding water EXCEPT
A:-Water molecules form dipoles B:-The angle between two hydrogen atoms in water molecule is 105°
C:-Has low dielectric constant D:-Is an excellent nucleophile
Ans: C
14:-Which of the following can be a cause of Normal Anion Gap Metabolic Acidosis?
A:-Organic aciduria B:-Salicylate poisoning C:-Acetazolamide therapy D:-Lactic acidosis
Ans: C
15:-All the following statements regarding pKa are true EXCEPT
A:-At pKa the ratio of salt to acid in a buffer is 2:1 B:-At pKa the buffer has maximum buffering capacity
C:-pKa of an acid is the pH at which the acid is half ionized D:-Weak acids have high pKa
Ans: A
16:-Which one of the following test is used to detect CSF globulins?
A:-Heller's test B:-Pandy's test C:-Oliver's test D:-Pettenkoffer's test
Ans: B
17:-Of the following which hypotheses claims that there is an association between the predictor and outcome variables?
A:-Alternative hypotheses B:-Null hypotheses C:-Statistical hypotheses D:-Composite hypotheses
Ans: A
18:-If mean is 25 and standard deviation is 5, then coefficient of variation is
A:-5% B:-20% C:-25% D:-75%
Ans: B
19:-Which of the following is the best test based on the ROC curve?
A:-Area under the curve is more than 0.9 B:-Area under the curve is 0.5
C:-Area under the curve is less than 0.1 D:-Area under the curve is less than 0.01
Ans: A
20:-Which one of the following statements is NOT TRUE regarding telomerase?
A:-It's activity is increased in cancer B:-Loss of telomerase activity leads to aging
C:-It is a ribozyme D:-It has reverse transcriptase activity
Ans: C
21:-Assertion: Phenyl alanine is a ketogenic amino acid.
Reason : Catabolism of phenylalanine yields fumarate that enters into TCA cycle.
a) If both A and R are true and R is correct explanation of A
b) If both A and R are true but R is not the correct explanation of A
c) If R is true but A is false
d) If both A and R are false.
Ans: Both A and R are true but R is not the correct explanation of A
22:-Which one of the following molecular techniques is used to detect a specific RNA?
A:-Southern blot technique B:-Northern blot technique C:-Western blot technique D:-In situ hybridization
Ans: B
23:-Which one of the following features about genetic code is INCORRECT?
A:-Non-degenerate B:-Non-ambiguous C:-Non-overlapping D:-Continuous
Ans: A
24:-Which one of the following conditions results from defective alpha oxidation?
A:-Methyl malonic aciduria B:-Glutaric aciduria C:-Refsum's disease D:-Propionic acidemia
Ans: C
25:-Which one of the following amino acids is purely ketogenic?
A:-Leucine B:-Isoleucine C:-Lysine D:-Phenyl alanine
Ans: A
26:-All the following conditions show low serum AFP level EXCEPT
A:-Down syndrome B:-Anencephaly C:-Trisomy 18 D:-Turners syndrome
Ans: B
27:-All the following statements regarding glutathione are true EXCEPT
A:-It favours the absorption of neutral amino acids in the intestine B:-It inactivates insulin
C:-It is an atypical tripeptide D:-It plays an important role in free radical scavenging
Ans: B
28:-Which one of the following is NOT a post-transcriptional modification?
A:-5' capping B:-Poly-A tailing C:-Acetylation D:-Methylation
Ans: C
29:-Select the FALSE statement regarding phosphofructokinase 1.
A:-It is activated by AMP B:-Fructose 2,6 bisphosphate inhibits this enzyme
C:-During starvation the synthesis of this enzyme is repressed D:-Fructose 6 phosphate activates this enzyme
Ans: B
30:-All the following statements regarding pentose phosphate pathway is correct EXCEPT
A:-Glucose-6-phosphate dehydrogenase is the rate limiting enzyme of the pathway
B:-In RBCs it is the only source of NADPH for free radical scavenging
C:-No ATP is produced in this pathway
D:-Glucose-6-phosphate dehydrogenase is inhibited by insulin
Ans: D
31:-Which one of the following statements about glycogen metabolism is INCORRECT?
A:-Glucagon enhances glycogenolysis in muscle
B:-Epinephrine enhances glycogenolysis in liver and muscle
C:-Glycogenolysis in liver will lead to increase in blood glucose level
D:-Pyridoxal phosphate is essential for glycogenolysis in muscle
Ans: A
32:-Regarding pancreatic lipase the INCORRECT statement is
A:-It is a glycoprotein
B:-It's serum level is increased in renal insufficiency
C:-It has a specificity of 80-100% in diagnosing acute pancreatitis
D:-It's serum level increases within 8 to 12 hours and reaches a peak by 48 hours after an acute attack of pancreatitis
Ans: D
33:-Which is the soluble storage form of iron in tissues?
A:-Ferritin B:-Transferrin C:-Hemosiderin D:-Haptoglobin
Ans: A
34:-Black liver jaundice is seen in
A:-Dubin Johnson syndrome B:-Rotor syndrome
C:-Glibert's disease D:-Crigler-Najjar syndrome
Ans: A
35:-Select the neurotransmitter synthesized from tyrosine
A:-GABA B:-Melatonin C:-Dopamine D:-Serotonin
Ans: C
36:-Which of the following is used for staining DNA fragments in electrophoresis?
A:-Coomasssie Brilliant Blue B:-Nitrotetrazolium Blue C:-Silver Nitrate D:-Ethidium Bromide
Ans: D
37:-Which liver enzyme is best for detecting biliary obstruction?
A:-Alanine amino transferase B:-Alkaline phosphatase C:-Nucleotide phosphatase D:-Gamma glutamyl transferase
Ans: C
38:-Which of the following statement is NOT true regarding oncogenes?
A:-Mutation in one of the two alleles is sufficient to produce oncogenic effects
B:-Oncogenic effect is due to gain of function of a protein that stimulates cell growth and proliferation
C:-Mutations in oncogenes may be present in somatic or germ cells
D:-Usually do not show tissue preference with respect to the type of cancers in which they are found
Ans: C
39:-All the following are multienzyme complexes EXCEPT
A:-Pyruvate carboxylase B:-Alpha keto dehydrogenase C:-Acetyl Co A carboxylase D:-Pyruvate kinase
Ans: D
40:-Which of the following is an example for non-competitive inhibition?
A:-Allopurinol inhibits xanthine oxidase B:-Fluoride inhibits enolase
C:-5-fluorouracil inhibits thymidylate synthase D:-Lovastatin inhibits HMG Co A reductase
Ans: B
41:-Which one of the following diseases results from defective nucleotide excision repair mechanism?
A:-Xeroderma Pigmentosum B:-Hereditary Polyposis Colon Cancer
C:-Fanconi's Anemia D:-Bloom's Syndrome
Ans: A
42. In a membrane, carbohydrate moieties glycoproteins or glycolipids are
A. oriented towards outside B. placed towards inside
C. facing towards outside and inside D. randomly dispersed
Ans: A
43. The bilayered lipid bilayer ______ in nature
A. hydrophilic B. hydrophobic C. both D. the nature depends on the immediateenvironment
Ans: C
44. __________membrane contains the largest amount of proteins
A. red blood corpuscular membrane B. myelin sheath C. lyzosomalmembrane D. outer mitochondrial membrane
Ans:A
45. The distribution of inherent proteins in the membrane:
A. symmetrical B. asymmetrical C. random D. uniform
Ans: B
46. _________statement describes the role of a cell membrane?
A. free entry and exit of substances into or out of a cell B. controlled movement of substances across.
C. Block the entry of substances into the cell. D. Dismissess the exit of substances from the cell.
Ans: B
47. Generally, Non-essential amino acids are synthesized by _________ reactions.
a) Oxidative deamination b) Oxidative decarboxylation c) Transamination d) Non-oxidative deamination
Ans: C
48. Essential Aminoacids
a) are synthesized in the liver b) are only used in the synthesis of proteins
c) cannot be synthesized in the body d) are only catabolized to urea
Ans: C
49. Transamination involves
a) exchange of amino groups between a ketoacid and an aminoacid
b) addition of keto groups from a ketoacid to an aminoacid
c) transfer of amino groups from a ketoacid to an aminoacid
d) all the above
Ans: A
50. The coenzyme involved in transamination is
a) Pyridoxal phosphate b) Coenzyme Q c) Thiamine d) Pyridoxamine Phosphate
Ans: A
51. Serum Transaminases are significant markers for
a) Liver diseases b) Heart Diseases c) Both a and b d) None of the above
Ans: C
52. In ureotelic animals, the amino group is excreted as
a) Ammonia b) Urea and Uric Acid c) Urea d) Uric acid
Ans: C
53. Carbamoyl Phosphate Synthetase –II is present in the
a) Mitochondria b) Cytosol c) Partly mitochondria and partly in the cytosol d) Nucleus
Ans: B
54. DOPA is
a) Dehydroxyphenylalanine b) Dihydroxyphenylacetate
c) Dihydroxyphenylalanine d) Dehydrophenylalanine
Ans: C
55. The first step in the catabolism of amino acids is
a) Removal of its amino group b) Removal of the carboxyl group
c) Removal of the carbon skeleton d) Removal of methyl group
Ans: A
56. _______________ serves as a precursor for dopamine
a) Tryptophan b) Hydroxyproline c) Tyrosine d) Proline
Ans: C
57. The _________ reaction is catalyzed by the glutamate dehydrogenase with ______ as the co-enzyme.
a) Irreversible and NADH+/NADPH+ b) Irreversible and NAD+/NADP+
c) Reversible and NAD+/NADP+ d) Reversible and NADH+/NADPH+
Ans: C
58. __________ amino acids are both glucogenic and ketogenic in nature.
a) Isoleucine and tyrosine
b) Glycine and alanine
c) Leucine and lysine
d) Aspartate and glutamate
Ans: A
59. ________ acts as a methyl donor for the synthesis of epinephrine, creatine and thymine.
a) Methotrexate b) S- adenosyl methionine c) Tetrahydrofolate d) Biotin
Ans: B
60. Catabolism of phenylalanine and tyrosine yield _____.
a) Succinate b) α-ketoglutarate c) Malate d) Fumarate
Ans: D
61. Co-enzyme required for the conversion of L-Amino acid into L-Imino acid.
a) FAD+ b) FMN c) NAD+ d) NADP+
Ans: B
Direction: In each of the following questions (62-65) a statement of assertion (A) is given and a corresponding statement of reason (R) is given just below it. Mark the correct statement
62. Assertion: GDH plays a major role in nitrogen metabolism.
Reason : Glutamate acts as a sink for amino groups of amino acid.
a) If both A and R are true and R is correct explanation of A
b) If both A and R are true but R is not the correct explanation of A
c) If R is true but A is false
d) If both A and R are false.
Ans: Both A and R are true and R is correct explanation of A
63. Assertion: Defects in urea cycle will affect brain.
Reason : Depletion of α-ketoglutarate occurs due to its conversion to glutamate.
a) If both A and R are true and R is correct explanation of A
b) If both A and R are true but R is not the correct explanation of A
c) If R is true but A is false
d) If both A and R are false.
Ans: Both A and R are true and R is correct explanation of A
64. Assertion: α-ketobutyric acid is formed by transamination reaction.
Reason : Transamination reaction catalyses the inter-conversion of ketoacid and amino acid.
a) If both A and R are true and R is correct explanation of A
b) If both A and R are true but R is not the correct explanation of A
c) If R is true but A is false
d) If both A and R are false.
Ans: R is true but A is false
65. Assertion: Essential amino acid are synthesized from α-keto acid by the transfer of amino group with the help of transaminases. Reason : Transfer of amino group occurs during synthesis and degradation of amino acid.
a) If both A and R are true and R is correct explanation of A
b) If both A and R are true but R is not the correct explanation of A
c) If R is true but A is false
d) If both A and R are false.
Ans: R is true but A is false
Ques # :66
Increased urinary excretion of uroblinogen is observed in
1) Hemolytic jaundice
2) Hepatic jaundice
3) Obstructive jaundice
4) All of them
Ans: 1
Ques # :67
Kidneys regulate electrolyte balance through
1) Aldosterone
2) Atrial natriuretic factor
3) Bradykinin and Kallidin
4) All of them
Ans: 4
Ques # :68
Clinical manifestation of Kwashiorkor includes EXCEPT
1) Oedema
2) Diarrhoea
3) Moon face
4) Emaciation
Ans: 4
Ques # :69
Minamata disease is due to toxicity of:
1) Mercury
2) Arsenic
3) Cadmium
4) Lead
Ans: 1
Ques # :70
Which immunoglobulin mediates primary immune response
1) Ig G
2) Ig A
3) Ig M
4) Ig D
Ans: 3
Ques # :71
High degree of fidelity during replication is maintained by:
1) DNA topoisomerase
2) DNA Helicase
3) DNA polymerase
4) DNA ligase
Ans: 3
Ques # :72
The promotors elements of transcription are present on:
1) Template strand
2) Coding strand
3) RNA polymerase
4) hn-RNA
Ans: 2
Ques # :73
Which one is antioncogene:
1) c-ras
2) v-ras
3) c-myc
4) RB1
Ans: 4
Ques # :74
All the following are glycoproteins EXCEPT:
1) TSH
2) Globosides
3) Alkaline Phosphotase
4) Lectins
Ans: 2
Ques # :75
The property of surface tension is applied in all processes except:
1) Digestion and Absorption of fats
2) Exchange of gases in lungs
3) Oedema due to hypoalbuminemia
4) Detections of bile salts in urine
Ans: 3
Ques # :76
One amino acid may have more than one codon. The property of genetic code is :
1) Degeneracy
2) Specificity
3) Universality
4) Unambiguity
Ans: 1
Ques # :77
Tumour marker associated with carcinoma thyroid gland:
1) Alphafetoprotein
2) CA-125
3) Calcitonin
4) Neuron specific enolase
Ans: 3
Ques # :78
Hormone that causes obesity
1) Laptin
2) Ghrelin
3) Adiponectin
4) PYY-36
Ans: 2
Ques # :79
Compound acting as inhibitor of complex-I of electron transport chain
1) Malonate
2) Amobarbital
3) Antimycin-A
4) Cyanide
Ans: 2
Ques # :80
Level of structural organization preserved during denaturation of proteins:
1) Primary
2) Secondary
3) Tertiary
4) Quaternary
Ans: 1
Ques # :81
Cardiolipin is associated with
1) Barth syndrome
2) Parkinson's disease
3) Tangier's disease
4) All of them
Ans: 4
Ques # :82
The nitrogen atoms in urea originates from:
1) Ammonia and alanine
2) Ammonia and glutamine
3) Glutamate and aspartate
4) Alanine and aspartate
Ans: 3
Ques # :83
Barlows disease is due to deficiency of :
1) Vitamin-A
2) Vitamin-C
3) Vitamin-K
4) Vitamin-B3
Ans: 2
Ques # :84
Argentaffinomas in malignant carcinoid are usually seen in cells of :
1) Brain
2) Gastrointestinal tract
3) Heart
4) Lungs
Ans: 2
Ques # :85
The compound providing color to stool is :
1) Bilirubin
2) Stercobilinogen
3) Stercobilin
4) Urobilinogen
Ans: 3
Ques # :86
the amino acid required for the synthesis of Nitric oxide
1) Alanine
2) Argininoosuccinate
3) Tryptophan
4) Arginine
Ans: 4
Ques # :87
Regulatory gene in Lac-operon is:
1) Lac-I
2) Lac-Z
3) Lac-Y
4) Lac-A
Ans: 1
Ques # :88
Inhibition of glycolysis by oxygen is known as:
1) Krebs effect
2) Hills effect
3) Cori's effect
4) Pasteur effect
Ans: 4
Ques # :89
The hormone that stimulates mammotropic and lactogenic action is
1) TSH
2) Prolactin
3) LH
4) Progestrone
Ans: 2
Ques # :90
The Biochemical marker for the assessment of lipid peroxidation is:
1) Hydroperoxide
2) Reactive hydrogen species
3) Malondialdehyde
4) Ceruloplasmin
Ans: 3
Ques # :91
The nucleotide used in the treatment of orotic aciduria is:
1) Adenosine
2) Guanosine
3) Thymidine
4) Uridine
Ans: 4
Ques # :92
Bence Jones protein in urine is detected by:
1) FIGLU test
2) Bradshaw's test
3) Hay's test
4) Rothera's test
Ans: 2
Ques # :93
Which type of solution is used to reduce the intracranial pressure?
1) Isotonic
2) Hypotonic
3) Hypertonic
4) Colloidal
Ans: 3
Ques # :94
Choline plays role in all except
1) Transmethylation
2) Nerve transmission
3) Blood coagulation
4) Lipotropic factor
Ans: 3
Ques # :95
In-vitro techniques used for the production of monoclonal antibodies is :
1) Recombinant DNA technology
2) Hybridoma technology
3) Polymerase chain reaction
4) ELISA
Ans: 2
Ques # :96
The most damaging radiation to the tissues are
1) Alpha rays
2) Beta rays
3) Gamma rays
4) Radiowaves
Ans: 1
Ques # :97
Disease related to diffective repair of DNA damage are all except
1) Xeroderma pigmentosum
2) Prion Disease
3) Cockayne syndrome
4) Ataxia telangiectasia
Ans: 2
Ques # :98
Carnitine is sythesized from amino acids
1) Lysine and cysteine
2) Lysine and arginine
3) Lysine and glycine
4) Lysine and Methionine
Ans: 4
Ques # :99
Release of which hormone from endronic gland is facilitated by calcium ions
1) Insulin
2) PTH
3) Calcitonin
4) All of them
Ans: 4
Ques # :100
Hypoxia Occuring in high altitudes causes
1) Metabolic acidosis
2) Respiratory alkalosis
3) Metabolic acidosis
4) Respiratory acidosis
Ans: 2
a) Liver diseases b) Heart Diseases c) Both a and b d) None of the above
Ans: C
52. In ureotelic animals, the amino group is excreted as
a) Ammonia b) Urea and Uric Acid c) Urea d) Uric acid
Ans: C
53. Carbamoyl Phosphate Synthetase –II is present in the
a) Mitochondria b) Cytosol c) Partly mitochondria and partly in the cytosol d) Nucleus
Ans: B
54. DOPA is
a) Dehydroxyphenylalanine b) Dihydroxyphenylacetate
c) Dihydroxyphenylalanine d) Dehydrophenylalanine
Ans: C
55. The first step in the catabolism of amino acids is
a) Removal of its amino group b) Removal of the carboxyl group
c) Removal of the carbon skeleton d) Removal of methyl group
Ans: A
56. _______________ serves as a precursor for dopamine
a) Tryptophan b) Hydroxyproline c) Tyrosine d) Proline
Ans: C
57. The _________ reaction is catalyzed by the glutamate dehydrogenase with ______ as the co-enzyme.
a) Irreversible and NADH+/NADPH+ b) Irreversible and NAD+/NADP+
c) Reversible and NAD+/NADP+ d) Reversible and NADH+/NADPH+
Ans: C
58. __________ amino acids are both glucogenic and ketogenic in nature.
a) Isoleucine and tyrosine
b) Glycine and alanine
c) Leucine and lysine
d) Aspartate and glutamate
Ans: A
59. ________ acts as a methyl donor for the synthesis of epinephrine, creatine and thymine.
a) Methotrexate b) S- adenosyl methionine c) Tetrahydrofolate d) Biotin
Ans: B
60. Catabolism of phenylalanine and tyrosine yield _____.
a) Succinate b) α-ketoglutarate c) Malate d) Fumarate
Ans: D
61. Co-enzyme required for the conversion of L-Amino acid into L-Imino acid.
a) FAD+ b) FMN c) NAD+ d) NADP+
Ans: B
Direction: In each of the following questions (62-65) a statement of assertion (A) is given and a corresponding statement of reason (R) is given just below it. Mark the correct statement
62. Assertion: GDH plays a major role in nitrogen metabolism.
Reason : Glutamate acts as a sink for amino groups of amino acid.
a) If both A and R are true and R is correct explanation of A
b) If both A and R are true but R is not the correct explanation of A
c) If R is true but A is false
d) If both A and R are false.
Ans: Both A and R are true and R is correct explanation of A
63. Assertion: Defects in urea cycle will affect brain.
Reason : Depletion of α-ketoglutarate occurs due to its conversion to glutamate.
a) If both A and R are true and R is correct explanation of A
b) If both A and R are true but R is not the correct explanation of A
c) If R is true but A is false
d) If both A and R are false.
Ans: Both A and R are true and R is correct explanation of A
64. Assertion: α-ketobutyric acid is formed by transamination reaction.
Reason : Transamination reaction catalyses the inter-conversion of ketoacid and amino acid.
a) If both A and R are true and R is correct explanation of A
b) If both A and R are true but R is not the correct explanation of A
c) If R is true but A is false
d) If both A and R are false.
Ans: R is true but A is false
65. Assertion: Essential amino acid are synthesized from α-keto acid by the transfer of amino group with the help of transaminases. Reason : Transfer of amino group occurs during synthesis and degradation of amino acid.
a) If both A and R are true and R is correct explanation of A
b) If both A and R are true but R is not the correct explanation of A
c) If R is true but A is false
d) If both A and R are false.
Ans: R is true but A is false
Ques # :66
Increased urinary excretion of uroblinogen is observed in
1) Hemolytic jaundice
2) Hepatic jaundice
3) Obstructive jaundice
4) All of them
Ans: 1
Ques # :67
Kidneys regulate electrolyte balance through
1) Aldosterone
2) Atrial natriuretic factor
3) Bradykinin and Kallidin
4) All of them
Ans: 4
Ques # :68
Clinical manifestation of Kwashiorkor includes EXCEPT
1) Oedema
2) Diarrhoea
3) Moon face
4) Emaciation
Ans: 4
Ques # :69
Minamata disease is due to toxicity of:
1) Mercury
2) Arsenic
3) Cadmium
4) Lead
Ans: 1
Ques # :70
Which immunoglobulin mediates primary immune response
1) Ig G
2) Ig A
3) Ig M
4) Ig D
Ans: 3
Ques # :71
High degree of fidelity during replication is maintained by:
1) DNA topoisomerase
2) DNA Helicase
3) DNA polymerase
4) DNA ligase
Ans: 3
Ques # :72
The promotors elements of transcription are present on:
1) Template strand
2) Coding strand
3) RNA polymerase
4) hn-RNA
Ans: 2
Ques # :73
Which one is antioncogene:
1) c-ras
2) v-ras
3) c-myc
4) RB1
Ans: 4
Ques # :74
All the following are glycoproteins EXCEPT:
1) TSH
2) Globosides
3) Alkaline Phosphotase
4) Lectins
Ans: 2
Ques # :75
The property of surface tension is applied in all processes except:
1) Digestion and Absorption of fats
2) Exchange of gases in lungs
3) Oedema due to hypoalbuminemia
4) Detections of bile salts in urine
Ans: 3
Ques # :76
One amino acid may have more than one codon. The property of genetic code is :
1) Degeneracy
2) Specificity
3) Universality
4) Unambiguity
Ans: 1
Ques # :77
Tumour marker associated with carcinoma thyroid gland:
1) Alphafetoprotein
2) CA-125
3) Calcitonin
4) Neuron specific enolase
Ans: 3
Ques # :78
Hormone that causes obesity
1) Laptin
2) Ghrelin
3) Adiponectin
4) PYY-36
Ans: 2
Ques # :79
Compound acting as inhibitor of complex-I of electron transport chain
1) Malonate
2) Amobarbital
3) Antimycin-A
4) Cyanide
Ans: 2
Ques # :80
Level of structural organization preserved during denaturation of proteins:
1) Primary
2) Secondary
3) Tertiary
4) Quaternary
Ans: 1
Ques # :81
Cardiolipin is associated with
1) Barth syndrome
2) Parkinson's disease
3) Tangier's disease
4) All of them
Ans: 4
Ques # :82
The nitrogen atoms in urea originates from:
1) Ammonia and alanine
2) Ammonia and glutamine
3) Glutamate and aspartate
4) Alanine and aspartate
Ans: 3
Ques # :83
Barlows disease is due to deficiency of :
1) Vitamin-A
2) Vitamin-C
3) Vitamin-K
4) Vitamin-B3
Ans: 2
Ques # :84
Argentaffinomas in malignant carcinoid are usually seen in cells of :
1) Brain
2) Gastrointestinal tract
3) Heart
4) Lungs
Ans: 2
Ques # :85
The compound providing color to stool is :
1) Bilirubin
2) Stercobilinogen
3) Stercobilin
4) Urobilinogen
Ans: 3
Ques # :86
the amino acid required for the synthesis of Nitric oxide
1) Alanine
2) Argininoosuccinate
3) Tryptophan
4) Arginine
Ans: 4
Ques # :87
Regulatory gene in Lac-operon is:
1) Lac-I
2) Lac-Z
3) Lac-Y
4) Lac-A
Ans: 1
Ques # :88
Inhibition of glycolysis by oxygen is known as:
1) Krebs effect
2) Hills effect
3) Cori's effect
4) Pasteur effect
Ans: 4
Ques # :89
The hormone that stimulates mammotropic and lactogenic action is
1) TSH
2) Prolactin
3) LH
4) Progestrone
Ans: 2
Ques # :90
The Biochemical marker for the assessment of lipid peroxidation is:
1) Hydroperoxide
2) Reactive hydrogen species
3) Malondialdehyde
4) Ceruloplasmin
Ans: 3
Ques # :91
The nucleotide used in the treatment of orotic aciduria is:
1) Adenosine
2) Guanosine
3) Thymidine
4) Uridine
Ans: 4
Ques # :92
Bence Jones protein in urine is detected by:
1) FIGLU test
2) Bradshaw's test
3) Hay's test
4) Rothera's test
Ans: 2
Ques # :93
Which type of solution is used to reduce the intracranial pressure?
1) Isotonic
2) Hypotonic
3) Hypertonic
4) Colloidal
Ans: 3
Ques # :94
Choline plays role in all except
1) Transmethylation
2) Nerve transmission
3) Blood coagulation
4) Lipotropic factor
Ans: 3
Ques # :95
In-vitro techniques used for the production of monoclonal antibodies is :
1) Recombinant DNA technology
2) Hybridoma technology
3) Polymerase chain reaction
4) ELISA
Ans: 2
Ques # :96
The most damaging radiation to the tissues are
1) Alpha rays
2) Beta rays
3) Gamma rays
4) Radiowaves
Ans: 1
Ques # :97
Disease related to diffective repair of DNA damage are all except
1) Xeroderma pigmentosum
2) Prion Disease
3) Cockayne syndrome
4) Ataxia telangiectasia
Ans: 2
Ques # :98
Carnitine is sythesized from amino acids
1) Lysine and cysteine
2) Lysine and arginine
3) Lysine and glycine
4) Lysine and Methionine
Ans: 4
Ques # :99
Release of which hormone from endronic gland is facilitated by calcium ions
1) Insulin
2) PTH
3) Calcitonin
4) All of them
Ans: 4
Ques # :100
Hypoxia Occuring in high altitudes causes
1) Metabolic acidosis
2) Respiratory alkalosis
3) Metabolic acidosis
4) Respiratory acidosis
Ans: 2