BIOCHEMISTRY- MEDICAL DEPARTMENT- PAGE 5
BIOCHEMISTRY- MEDICAL DEPARTMENT MCQs
1. Achlorhydria condition is seen in:
1) Zollinger-Ellison syndrome
2) Gastric Carcinoma
3) Pernicious anemia
4) Duodenal ulcer
Ans: 3
2. Water excretion by kidneys is tightly regulated by:
1) Aldosterone
2) Epinephrine
3) Oxytocin
4) Vasopressin
Ans: 4
3. In replication the function of following enzyme is comparable with Zip opener
1) DNA Liagase
2) DNA Helicase
3) DNA Gyrase
4) DNA topoisomerase
Ans: 2
4. In translation, the number of high energy phosphate bonds used for incorporating a single
amino acid is
1) 3
2) 4
3) 5
4) 6
Ans: 2
5. Oncogenic virus which is not a DNA virus
1) Adenovirus
2) Papovirus
3) Retro virus
4) Herpes virus
Ans: 3
6. Seperation of molecules in electrophoresis depends on
1) Size
2) Charge
3) Magnitude of current
4) All of them
Ans: 4
7. Prostanoids includes all EXCEPT
1) Prostacyclins
2) Lipoxins
3) Thromboxanes
4) Prostaglandin
Ans: 2
8. Triple Helix structure is seen in
1) Collagen
2) Silk
3) Myoglobin
4) Hemoglobin
Ans: 1
9. Trehalose is :
1) Non reducing disaccharide
2) Major sugar of insect hemolymph
3) Hydrolyzed into two-α glucose molecule
4) All of them
Ans: 4
10. The Phase-I biotransformation includes all reactions except
1) Oxidation
2) Conjugation
3) Hydrolysis
4) Reduction
Ans: 2
Ques # :11
Acetyl CoA is an allosteric inhibitor of:
1) Succinate dehydrogenase
2) Malate dehydrogenase
3) Pyruvate dehydrogenase
4) Isocitrate dehydrogenase
Ans: 3
Ques # :12
Normal anion gap in plasma is about
1) 15 mEq/L
2) 10 mEq/L
3) 5 mEq/L
4) 0 mEq/L
Ans: 1
Ques # :13
pKa of dehydrogen phosphate is
1) 5.8
2) 6.1
3) 6.8
4) 7.1
Ans: 3
Ques # :14
Hypo-osmotic dehydration is the condition seen in :
1) Hypernatremia
2) Hyponatremia
3) Pulmonary edema
4) All
Ans: 2
Ques # :15
Congestive heart failure is characterized by
1) Increase plasma volume
2) Decreased plasma volume
3) Increased sodium loss
4) Decreased potassium retention
Ans: 1
Ques # :16
Osmoreceptors are present in
1) Capillaries
2) Aortic arch
3) Carotid sinus
4) Hypothalamus
Ans: 4
Ques # :17
Vitamin used in the management of hyperlipidemia
1) Niacin
2) Folic acid
3) Cobalamine
4) Thymine
Ans: 1
Ques # :18
Cystatin C is marker for
1) Distal tubular function
2) Renin angeotensin system
3) Glomerular function
4) none of them
Ans: 3
Ques # :19
Ferrochelatase is deficient in
1) Acute intermittent porphyria
2) Porphiria cutanea
3) Hereditary corproporphyria
4) Protoporphyria
Ans: 4
Ques # :20
A person on a fat free carbohydrate rich diet continues to grow obese. Which of the following lipoprotein is likely to be elevated in his blood
1) Chylomicrons
2) VLDL
3) LDL
4) HDL
Ans: 2
Ques # :21
The RDA for lipids per day for normal adults is:
1) 20 gms
2) 45 gms
3) 40 gms
4) 50 gms
Ans: 1
Ques # :22
Hormone response elements are located in:
1) Nucleus
2) Mitochondria
3) Cell membrane
4) Cytosol
Ans: 1
Ques # :23
CD 4 is a transmembrane protein present in
1) Plasma cells
2) Cytotoxic C cells
3) Helper T cells
4) Suppressor T cells
Ans: 3
Ques # :24
Antibodies are classified on the basis of their :
1) Size
2) Heavy chains
3) Light chains
4) Idiotypes
Ans: 2
Ques # :25
The antibody present in lowest concentration in plasma
1) Ig E
2) Ig D
3) Ig G
4) Ig A
Ans: 1
Ques # :26
The genes for the light chains of Immunoglobulins are located on chromosomes
1) 2 and 22
2) 2 and 14
3) 2 and 16
4) 2 and 10
Ans: 1
Ques # :27
Waldenstrom's macroglobulinemia occurs due to increase of
1) Ig A
2) Ig M
3) Ig D
4) Ig G
Ans: 2
Ques # :28
Ciprofloxacin inhibits the synthesis of :
1) m RNA
2) DNA
3) t RNA
4) r RNA
Ans: 2
Ques # :29
Which of the following is not a protein misfolding disorder
1) Tuberculosis
2) Alzheimer's disease
3) Cystic fibrosis
4) Prion disease
Ans: 1
Ques # :30
Which type of RNA has the highest percentage of modified base
1) m RNA
2) t RNA
3) r RNA
4) Sn RNA
Ans: 2
Ques # :31
The first gene therapy in human was carried out by French Anderson in:
1) 1990
2) 1970
3) 1980
4) 1995
Ans: 1
Ques # :32
Aging cell will release iron with the help of a copper containing protein called
1) Hepcidin
2) Hephaestin
3) Hemosiderin
4) Hemopexin
Ans: 2
Ques # :33
Which monosaccharide causes sequestering of phosphate in cell
1) Glucose
2) Fructose
3) Ribose
4) Galactose
Ans: 2
Ques # :34
Amino acid with thio-ether group is
1) Cysteine
2) Histidine
3) Methionine
4) Threonine
Ans: 3
Ques # :35
Hydrolysis of ATP into ADP and Pi liberates energy of
1) 3.4 kcal/mol
2) 5.0 kcal/mol
3) 7.3 kcal/mol
4) 10.3 kcal/mol
Ans: 3
Ques # :36
Enzyme used as a therapeutic agent
1) Asparaginase
2) Gamma glutamyltransferase
3) Taq Polymerase
4) Restriction endonuclease
Ans: 1
Ques # :37
Which molecular form of vitamine- A has role in skin disease
1) Beta-carotene
2) Retinol
3) Retinoic acid
4) Retinal
Ans: 3
Ques # :38
Peptide linkage is present in which vitamine structure
1) Riboflavin
2) Pantothenic acid
3) Biotin
4) Niacin
Ans: 2
Ques # :39
Iodide pump in thyroid gland functions by:
1) Primary active transport system
2) Carrier type transport system
3) Vesicular type transport system`
4) Secondary active transport system
Ans: 4
Ques # :40
Detoxification of methanol and ethanol is done through
1) Hydrolysis
2) Oxidation
3) Reduction
4) Conjugation
Ans: 2
Ques # :41
Major cause of metabolic acidosis is:
1) Overdose of narcotics
2) Potassium deficiency
3) Hepatic failure
4) Diabetic ketoacidosis
Ans: 4
Ques # :42
Specific Dynamic Action(SDA) is highest for
1) Carbohydrates
2) Lipids
3) Proteins
4) Vitamins
Ans: 3
Ques # :43
Dietary fibers have beneficial effects in:
1) Cancers
2) Diabetes mellitus
3) Obesity
4) All of them
Ans: 4
Ques # :44
Trace metal used for prevention of peroxidation of lipids
1) Selenium
2) Chromium
3) Cobalt
4) Molybdenum
Ans: 1
Ques # :45
Disease associated with impaired synthesis of collagen protein
1) Scurvy
2) Alport syndrome
3) Ehlers-Danlos syndrome
4) all of them
Ans: 4
Ques # :46
Pauly's test is for the presence of
1) Histidine
2) Arginine
3) Tyrosine
4) Tryptophan
Ans: 1
Ques # :47
Allopurinol is structural analog of:
1) Hypoxanthine
2) Xanthine
3) Uric acid
4) Alloxanthine
Ans: 1
Ques # :48
In myocardial infaction serum level of the which LDH enzyme is elevated :
1) LDH-1
2) LDH-3
3) LDH-4
4) LDH-5
Ans: 1
Ques # :49
Hydroxylatiom of 25-hydroxycholecalciferol by 1-α hydroxylase occurs in :
1) Skin
2) Liver
3) Kidneys
4) Intestine
Ans: 3
Ques # :50
Eating excess raw eggs causes deficiency of
1) Riboflavin
2) Niacin
3) Folic acid
4) Biotin
Ans: 4
1) Zollinger-Ellison syndrome
2) Gastric Carcinoma
3) Pernicious anemia
4) Duodenal ulcer
Ans: 3
2. Water excretion by kidneys is tightly regulated by:
1) Aldosterone
2) Epinephrine
3) Oxytocin
4) Vasopressin
Ans: 4
3. In replication the function of following enzyme is comparable with Zip opener
1) DNA Liagase
2) DNA Helicase
3) DNA Gyrase
4) DNA topoisomerase
Ans: 2
4. In translation, the number of high energy phosphate bonds used for incorporating a single
amino acid is
1) 3
2) 4
3) 5
4) 6
Ans: 2
5. Oncogenic virus which is not a DNA virus
1) Adenovirus
2) Papovirus
3) Retro virus
4) Herpes virus
Ans: 3
6. Seperation of molecules in electrophoresis depends on
1) Size
2) Charge
3) Magnitude of current
4) All of them
Ans: 4
7. Prostanoids includes all EXCEPT
1) Prostacyclins
2) Lipoxins
3) Thromboxanes
4) Prostaglandin
Ans: 2
8. Triple Helix structure is seen in
1) Collagen
2) Silk
3) Myoglobin
4) Hemoglobin
Ans: 1
9. Trehalose is :
1) Non reducing disaccharide
2) Major sugar of insect hemolymph
3) Hydrolyzed into two-α glucose molecule
4) All of them
Ans: 4
10. The Phase-I biotransformation includes all reactions except
1) Oxidation
2) Conjugation
3) Hydrolysis
4) Reduction
Ans: 2
Ques # :11
Acetyl CoA is an allosteric inhibitor of:
1) Succinate dehydrogenase
2) Malate dehydrogenase
3) Pyruvate dehydrogenase
4) Isocitrate dehydrogenase
Ans: 3
Ques # :12
Normal anion gap in plasma is about
1) 15 mEq/L
2) 10 mEq/L
3) 5 mEq/L
4) 0 mEq/L
Ans: 1
Ques # :13
pKa of dehydrogen phosphate is
1) 5.8
2) 6.1
3) 6.8
4) 7.1
Ans: 3
Ques # :14
Hypo-osmotic dehydration is the condition seen in :
1) Hypernatremia
2) Hyponatremia
3) Pulmonary edema
4) All
Ans: 2
Ques # :15
Congestive heart failure is characterized by
1) Increase plasma volume
2) Decreased plasma volume
3) Increased sodium loss
4) Decreased potassium retention
Ans: 1
Ques # :16
Osmoreceptors are present in
1) Capillaries
2) Aortic arch
3) Carotid sinus
4) Hypothalamus
Ans: 4
Ques # :17
Vitamin used in the management of hyperlipidemia
1) Niacin
2) Folic acid
3) Cobalamine
4) Thymine
Ans: 1
Ques # :18
Cystatin C is marker for
1) Distal tubular function
2) Renin angeotensin system
3) Glomerular function
4) none of them
Ans: 3
Ques # :19
Ferrochelatase is deficient in
1) Acute intermittent porphyria
2) Porphiria cutanea
3) Hereditary corproporphyria
4) Protoporphyria
Ans: 4
Ques # :20
A person on a fat free carbohydrate rich diet continues to grow obese. Which of the following lipoprotein is likely to be elevated in his blood
1) Chylomicrons
2) VLDL
3) LDL
4) HDL
Ans: 2
Ques # :21
The RDA for lipids per day for normal adults is:
1) 20 gms
2) 45 gms
3) 40 gms
4) 50 gms
Ans: 1
Ques # :22
Hormone response elements are located in:
1) Nucleus
2) Mitochondria
3) Cell membrane
4) Cytosol
Ans: 1
Ques # :23
CD 4 is a transmembrane protein present in
1) Plasma cells
2) Cytotoxic C cells
3) Helper T cells
4) Suppressor T cells
Ans: 3
Ques # :24
Antibodies are classified on the basis of their :
1) Size
2) Heavy chains
3) Light chains
4) Idiotypes
Ans: 2
Ques # :25
The antibody present in lowest concentration in plasma
1) Ig E
2) Ig D
3) Ig G
4) Ig A
Ans: 1
Ques # :26
The genes for the light chains of Immunoglobulins are located on chromosomes
1) 2 and 22
2) 2 and 14
3) 2 and 16
4) 2 and 10
Ans: 1
Ques # :27
Waldenstrom's macroglobulinemia occurs due to increase of
1) Ig A
2) Ig M
3) Ig D
4) Ig G
Ans: 2
Ques # :28
Ciprofloxacin inhibits the synthesis of :
1) m RNA
2) DNA
3) t RNA
4) r RNA
Ans: 2
Ques # :29
Which of the following is not a protein misfolding disorder
1) Tuberculosis
2) Alzheimer's disease
3) Cystic fibrosis
4) Prion disease
Ans: 1
Ques # :30
Which type of RNA has the highest percentage of modified base
1) m RNA
2) t RNA
3) r RNA
4) Sn RNA
Ans: 2
Ques # :31
The first gene therapy in human was carried out by French Anderson in:
1) 1990
2) 1970
3) 1980
4) 1995
Ans: 1
Ques # :32
Aging cell will release iron with the help of a copper containing protein called
1) Hepcidin
2) Hephaestin
3) Hemosiderin
4) Hemopexin
Ans: 2
Ques # :33
Which monosaccharide causes sequestering of phosphate in cell
1) Glucose
2) Fructose
3) Ribose
4) Galactose
Ans: 2
Ques # :34
Amino acid with thio-ether group is
1) Cysteine
2) Histidine
3) Methionine
4) Threonine
Ans: 3
Ques # :35
Hydrolysis of ATP into ADP and Pi liberates energy of
1) 3.4 kcal/mol
2) 5.0 kcal/mol
3) 7.3 kcal/mol
4) 10.3 kcal/mol
Ans: 3
Ques # :36
Enzyme used as a therapeutic agent
1) Asparaginase
2) Gamma glutamyltransferase
3) Taq Polymerase
4) Restriction endonuclease
Ans: 1
Ques # :37
Which molecular form of vitamine- A has role in skin disease
1) Beta-carotene
2) Retinol
3) Retinoic acid
4) Retinal
Ans: 3
Ques # :38
Peptide linkage is present in which vitamine structure
1) Riboflavin
2) Pantothenic acid
3) Biotin
4) Niacin
Ans: 2
Ques # :39
Iodide pump in thyroid gland functions by:
1) Primary active transport system
2) Carrier type transport system
3) Vesicular type transport system`
4) Secondary active transport system
Ans: 4
Ques # :40
Detoxification of methanol and ethanol is done through
1) Hydrolysis
2) Oxidation
3) Reduction
4) Conjugation
Ans: 2
Ques # :41
Major cause of metabolic acidosis is:
1) Overdose of narcotics
2) Potassium deficiency
3) Hepatic failure
4) Diabetic ketoacidosis
Ans: 4
Ques # :42
Specific Dynamic Action(SDA) is highest for
1) Carbohydrates
2) Lipids
3) Proteins
4) Vitamins
Ans: 3
Ques # :43
Dietary fibers have beneficial effects in:
1) Cancers
2) Diabetes mellitus
3) Obesity
4) All of them
Ans: 4
Ques # :44
Trace metal used for prevention of peroxidation of lipids
1) Selenium
2) Chromium
3) Cobalt
4) Molybdenum
Ans: 1
Ques # :45
Disease associated with impaired synthesis of collagen protein
1) Scurvy
2) Alport syndrome
3) Ehlers-Danlos syndrome
4) all of them
Ans: 4
Ques # :46
Pauly's test is for the presence of
1) Histidine
2) Arginine
3) Tyrosine
4) Tryptophan
Ans: 1
Ques # :47
Allopurinol is structural analog of:
1) Hypoxanthine
2) Xanthine
3) Uric acid
4) Alloxanthine
Ans: 1
Ques # :48
In myocardial infaction serum level of the which LDH enzyme is elevated :
1) LDH-1
2) LDH-3
3) LDH-4
4) LDH-5
Ans: 1
Ques # :49
Hydroxylatiom of 25-hydroxycholecalciferol by 1-α hydroxylase occurs in :
1) Skin
2) Liver
3) Kidneys
4) Intestine
Ans: 3
Ques # :50
Eating excess raw eggs causes deficiency of
1) Riboflavin
2) Niacin
3) Folic acid
4) Biotin
Ans: 4
Ques # :51
A salivary protein Gusten contains
1) Zinc
2) Manganese
3) Selenium
4) Chromium
Ans: 1
Ques # :52
The tubular maximum for glucose (TmG) is
1) .350 mg/min
2) .350 mg/dl
3) .350 mg/ml
4) .350 ml/min
Ans: 1
Ques # :53
Porphyria inherited as autosomal recessive disorder :
1) Erythropoietic protoporphyria
2) Congenital erythropoietic porphyria
3) Acute intermittent porphyria
4) Variegate porphyria
Ans: 2
A salivary protein Gusten contains
1) Zinc
2) Manganese
3) Selenium
4) Chromium
Ans: 1
Ques # :52
The tubular maximum for glucose (TmG) is
1) .350 mg/min
2) .350 mg/dl
3) .350 mg/ml
4) .350 ml/min
Ans: 1
Ques # :53
Porphyria inherited as autosomal recessive disorder :
1) Erythropoietic protoporphyria
2) Congenital erythropoietic porphyria
3) Acute intermittent porphyria
4) Variegate porphyria
Ans: 2