BIOCHEMISTRY- MEDICAL DEPARTMENT- PAGE 3
BIOCHEMISTRY- MEDICAL DEPARTMENT MCQs
1. Acetyl-CoA is oxidized in the TCA cycle and is used in liver and which one more organ/tissue for the biosynthesis of fatty acids and triacylglycerol :
1) Kidneys 2) Muscles 3) Adipose tissue 4) Large intestine
Ans: 3
2. Wernicke-korsackoff syndrome may occure due to
1) deficiency of G6PD 2) defective transketolase 3) Pyruvate kinase 4) Hexokinase
Ans: 2
3. Mucopolysaccharidoses are inherited lysosomal storage disease. They are caused by:
1) An increased rate of synthesis of carbohydrate component of proteoglycans
2) The synthesis of polysaccharides with an altered structure
3) An insufficient amount of proteolytic enzymes
4) Defects in the degradation of GAGs in proteoglycans
Ans: 4
4. Respiratory distress syndrome in premature infants is due to the deficiency of:
1) Plasmalogen 2) Dipalmitoyl lecithin 3) Cardiolipin 4) Cephalin
Ans: 2
5 . Virilization is caused by the deficiency of which of the hydroxylase
1) 17-hydroxylase 2) 11-hydroxylase 3) 21-hydroxylase 4) 22-hydroxylase
Ans: 3
6. Which of the following lipoprotein particles are most likely resposible for the milky appearance of the plasma
1) Chylomicrones 2) Very-low density lipoproteins 3) intermediate density lipoproteins 4) low-density lipoproteins
Ans: 1
7 . The following nucleoside is used in the treatment of oratic aciduria
1) Adenosine 2) Uridine 3) Guanosine 4) Thymidine
Ans: 2
8. which one of the following enzymes is used as an anticancer drug
1) Urokinase 2) Asparaginase 3) Streptokinase 4) papain
Ans: 2
9. All the following enzymes complexes of respiratory chain act as a proton pumps except
1) Complex-I 2) Complex-IV 3) Complex-II 4) Complex-III
Ans: 3
10. In rhodopsin, vitamin-A is in form of:
1) All-trans-retinal 2) 11-cis-retinol 3) 11-cis-retinal 4) All-trans-retinol
Ans: 3
11. Vitamin-C is essential for the post-translational modification of the following amino acid in collagen
1) Proline and Lysine 2) Histidine and Methionine 3) Proline and Cysteine 4) Lysine and Arginine
Ans: 1
12. Ingestion of sodium benzoate in man result in an increase in urinary excretion of :
1) Phenyl pyrivic acid 2) glyoxalic acid 3) Oxalic acid 4) Hippuric acid
Ans: 4
13. The limiting amino acid in rice and wheat protein are:
1) Cysteine,Methionine 2) Arginine,Histidine 3) Aspartate,glutamate 4) Lysine,Threonine
Ans: 4
14. Which of the following proteins provide tyrosine residues for iodination during thyroid hormone synthesis:
1) Thyroglobulin 2) Thyroid binding globulin 3) Thyroid binding prealbumin 4) all of the above
Ans: 1
15. Major Constituent of honey is:
1) Glucose 2) Galactose 3) Fructose 4) Mannose
Ans: 3
16. What is untrue of steroid hormone
1) steroid receptor complex enters nucleus 2) synthesized from cholesterol
3) binds to specific receptor protein in cytosol 4) stimulates adenyl cyclase activity
Ans: 4
17. Many antimicrobials inhibit protein translation. Which of the following antimicrobials is correctly paired with its mechanism of action 1) Tetracyclines inhibit peptidyltransferase
2) Diptheria toxin binds to the 30S ribosomal subunit
3) Puromycin inactivates EF-2
4) Erythromycin binds to the 50S ribosomal subunit
Ans: 4
18. which of the following is the basis for the intestine specific expression of apoprotein B-48
1) DNA rearrangement and loss 2) RNA editing 3) RNA alternative splicing 4) DNA transposition
Ans: 2
19. Which of the following is best described as being trans-acting
1) CAP site 2) Operator
3) Promoter 4) Repressor
Ans: 4
20. The DNA polymerase used in the polymerase chain reaction is derived from the following bacteria
1) Haemophilus aegypticus 2) Thermus aquaticus 3) Escherichia coli 4) Haemophilus influenzae
Ans: 2
21. The first human protein produced by recombinant technology
1) Casein 2) Albumin 3) Insulin 4) Growth hormone
Ans: 3
22. The mechnism of action of ras protein(a product of ras gene)involves the following signal transduction molecule
1) G-protein 2) ADP 3) cyclic AMP 4) GMP
Ans: 1
23. All the following oncogenic virus es are DNA viruses except:
1) human papilloma virus 2) retrovirus B 3) Epstein-Barr virus 4) herpes virus type-I
Ans: 2
24. All the following signalling molecules are involve in mediating the action of growth hormone at subcellular level , except
1) signal transducer and activators of transcription
2) Mitogen activator protein kinase
3) insuline receptor substrate and PI kinase
4) cyclic adenosine monophosphate
Ans: 4
25. All of the following sugars are found in glycoprotein, except:
1) fructose 2) fucose 3) xylose 4) galactose
Ans: 1
26. Which one of the following is not a source of oxygen radical
1) action of superoxide dismutase 2) activation of macrophages
3) ultraviolet radiation 4) reaction of beta-carotene with oxygen
Ans: 1
27. Which of the following is not a component of the cell's suite of damage repair and prevention agents
1) superoxide dismutase 2) Caspase-7 3) Glutothione 4) catalase
Ans: 2
28. An L-isomer of monosaccharide formed in human body is
1) L-fructose 2) L-Erythrose 3) L-Xylose 4) L-Xylulose
Ans: 4
29. The following is omega-3 polyunsaturated fatty acid
1) Linoleic acid 2) Alpha-Linolenic acid 3) Gamma-Linolenic acid 4) Arachidonic acid
Ans: 2
30. Acylsphingosine is also known as:
1) Sphingomylin 2) Ceramide 3) Cerebroside 4) Sulphatide
Ans: 2
31. Ribozymes are:
1) Protein enzymes acting on RNA 2) Catalytic RNAs
3) not substrate specific 4) Enzymes present in viruses
Ans: 2
32. Following myocardial infraction, the earliest serum enzymes to rise is:
1) creatine kinase 2) glutamate oxaloacetate transaminase
3) glutamate pyruvate transaminase 4) Lactate dehydrogenase
Ans: 1
33. Following myocardial infraction, serum creatine kinase returns to normal in about
1) 24 hrs 2) 3 days 3) 5 days 4) 7 days
Ans: 2
34. Cyanide inhibits the following complex of respiratory chain:
1) Complex II 2) Complex III 3) Complex IV 4) Complex V
Ans: 3
35. cytochrome oxidase is poisoned by the following except
1) oligomycin 2) hydrogen sulphide 3) carbon monoxide 4) cyanide
Ans: 1
36. Large doses of niacin
1) Increase serum cholesterol 2) decrease serum cholesterol
3) Increase serum pyruvate 4) decrease serum pyruvate
Ans: 2
37. Sigmoidal oxygen dissociation curve is property of:
1) Haemoglobin 2) carboxyhaemoglobin 3) myoglobin 4) Methaemoglobin
Ans: 1
38. Kernicterus can occur in :
1) Crigler-Najjar syndrome type I 2) Crigler-Najjar syndrome type II
3) Rotor's syndrome 4) Gilbert's syndrome
Ans: 1
39. Glucose is the only source of energy for:
1) Myocardium 2) Kidneys 3) Erythrocytes 4) Thrombocytes
Ans: 3
40. Dipalmitoyl Lecithin acts as:
1) Platelet activating factors 2) second messenger for hormones
3) lung surfactant 4) anti ketogenic compound
Ans: 3
41. Synthesis of prostaglandins is inhibited by:
1) Glucocorticoids 2) Glucagon 3) Insulin 4) Progesterone
Ans: 1
42. Aspirin inhibits:
1) Phospholipase C 2) Phospholipase D 3) Cyclo-oxygenase 4) Lipo-oxygenase
Ans: 3
43. Hyperuricaemia can occur due to all the following except
1) superactive phosphoribosyl pyrophosphate synthetase
2) hypoxanthine guanine phosphoribosyl transferase deficiency
3) Glucose-6 phophatase deficiency
4) Uricase deficiency
Ans: 4
44. Severe combined immunodeficiency disease (SCID)can result from deficiency
1) Adenosine kinase
2) Adenosine deaminase
3) Adenine phosphorobosyl transferase
4) hypoxanthine guanine phosphorobosyl transferase
Ans: 2
45. All the following can occur in Lesch-Nyhan syndrome except
1) Gouty arthritis 2) Uric acid stones 3) Retarded growth 4) Self- mutilating behavior
Ans: 3
46. Cyclins:
1) are circular DNA double helices 2) are circular polypeptides
3) are protein that regulates cell cycle 4) can undergo phosphorylation and dephosphorylations
Ans: 3
47. Rifampicin inhibits:
1) Unbinding of DNA 2) Initiation of replication 3) Initiation of translation 4) Initiation of transcription
Ans: 4
48. Peptidyl transferase activity of 50 S ribosomal subunits is inhibited by :
1) Rifampicin 2) Cycloheximide 3) Erythromycin 4) Chloramphenicol
Ans: 4
49. Inhibitors of mono amine oxidase prolong the life of :
1) gamma-aminobutyric acid 2) Melanin 3) Melatonin 4) Serotonin
Ans: 4
50. An extracellular fluid having a higher concentration of chloride than serum is
1) Bile 2) Sweat 3) Cerebrospinal fluid 4) Pancreatic juice
Ans: 3
1) Kidneys 2) Muscles 3) Adipose tissue 4) Large intestine
Ans: 3
2. Wernicke-korsackoff syndrome may occure due to
1) deficiency of G6PD 2) defective transketolase 3) Pyruvate kinase 4) Hexokinase
Ans: 2
3. Mucopolysaccharidoses are inherited lysosomal storage disease. They are caused by:
1) An increased rate of synthesis of carbohydrate component of proteoglycans
2) The synthesis of polysaccharides with an altered structure
3) An insufficient amount of proteolytic enzymes
4) Defects in the degradation of GAGs in proteoglycans
Ans: 4
4. Respiratory distress syndrome in premature infants is due to the deficiency of:
1) Plasmalogen 2) Dipalmitoyl lecithin 3) Cardiolipin 4) Cephalin
Ans: 2
5 . Virilization is caused by the deficiency of which of the hydroxylase
1) 17-hydroxylase 2) 11-hydroxylase 3) 21-hydroxylase 4) 22-hydroxylase
Ans: 3
6. Which of the following lipoprotein particles are most likely resposible for the milky appearance of the plasma
1) Chylomicrones 2) Very-low density lipoproteins 3) intermediate density lipoproteins 4) low-density lipoproteins
Ans: 1
7 . The following nucleoside is used in the treatment of oratic aciduria
1) Adenosine 2) Uridine 3) Guanosine 4) Thymidine
Ans: 2
8. which one of the following enzymes is used as an anticancer drug
1) Urokinase 2) Asparaginase 3) Streptokinase 4) papain
Ans: 2
9. All the following enzymes complexes of respiratory chain act as a proton pumps except
1) Complex-I 2) Complex-IV 3) Complex-II 4) Complex-III
Ans: 3
10. In rhodopsin, vitamin-A is in form of:
1) All-trans-retinal 2) 11-cis-retinol 3) 11-cis-retinal 4) All-trans-retinol
Ans: 3
11. Vitamin-C is essential for the post-translational modification of the following amino acid in collagen
1) Proline and Lysine 2) Histidine and Methionine 3) Proline and Cysteine 4) Lysine and Arginine
Ans: 1
12. Ingestion of sodium benzoate in man result in an increase in urinary excretion of :
1) Phenyl pyrivic acid 2) glyoxalic acid 3) Oxalic acid 4) Hippuric acid
Ans: 4
13. The limiting amino acid in rice and wheat protein are:
1) Cysteine,Methionine 2) Arginine,Histidine 3) Aspartate,glutamate 4) Lysine,Threonine
Ans: 4
14. Which of the following proteins provide tyrosine residues for iodination during thyroid hormone synthesis:
1) Thyroglobulin 2) Thyroid binding globulin 3) Thyroid binding prealbumin 4) all of the above
Ans: 1
15. Major Constituent of honey is:
1) Glucose 2) Galactose 3) Fructose 4) Mannose
Ans: 3
16. What is untrue of steroid hormone
1) steroid receptor complex enters nucleus 2) synthesized from cholesterol
3) binds to specific receptor protein in cytosol 4) stimulates adenyl cyclase activity
Ans: 4
17. Many antimicrobials inhibit protein translation. Which of the following antimicrobials is correctly paired with its mechanism of action 1) Tetracyclines inhibit peptidyltransferase
2) Diptheria toxin binds to the 30S ribosomal subunit
3) Puromycin inactivates EF-2
4) Erythromycin binds to the 50S ribosomal subunit
Ans: 4
18. which of the following is the basis for the intestine specific expression of apoprotein B-48
1) DNA rearrangement and loss 2) RNA editing 3) RNA alternative splicing 4) DNA transposition
Ans: 2
19. Which of the following is best described as being trans-acting
1) CAP site 2) Operator
3) Promoter 4) Repressor
Ans: 4
20. The DNA polymerase used in the polymerase chain reaction is derived from the following bacteria
1) Haemophilus aegypticus 2) Thermus aquaticus 3) Escherichia coli 4) Haemophilus influenzae
Ans: 2
21. The first human protein produced by recombinant technology
1) Casein 2) Albumin 3) Insulin 4) Growth hormone
Ans: 3
22. The mechnism of action of ras protein(a product of ras gene)involves the following signal transduction molecule
1) G-protein 2) ADP 3) cyclic AMP 4) GMP
Ans: 1
23. All the following oncogenic virus es are DNA viruses except:
1) human papilloma virus 2) retrovirus B 3) Epstein-Barr virus 4) herpes virus type-I
Ans: 2
24. All the following signalling molecules are involve in mediating the action of growth hormone at subcellular level , except
1) signal transducer and activators of transcription
2) Mitogen activator protein kinase
3) insuline receptor substrate and PI kinase
4) cyclic adenosine monophosphate
Ans: 4
25. All of the following sugars are found in glycoprotein, except:
1) fructose 2) fucose 3) xylose 4) galactose
Ans: 1
26. Which one of the following is not a source of oxygen radical
1) action of superoxide dismutase 2) activation of macrophages
3) ultraviolet radiation 4) reaction of beta-carotene with oxygen
Ans: 1
27. Which of the following is not a component of the cell's suite of damage repair and prevention agents
1) superoxide dismutase 2) Caspase-7 3) Glutothione 4) catalase
Ans: 2
28. An L-isomer of monosaccharide formed in human body is
1) L-fructose 2) L-Erythrose 3) L-Xylose 4) L-Xylulose
Ans: 4
29. The following is omega-3 polyunsaturated fatty acid
1) Linoleic acid 2) Alpha-Linolenic acid 3) Gamma-Linolenic acid 4) Arachidonic acid
Ans: 2
30. Acylsphingosine is also known as:
1) Sphingomylin 2) Ceramide 3) Cerebroside 4) Sulphatide
Ans: 2
31. Ribozymes are:
1) Protein enzymes acting on RNA 2) Catalytic RNAs
3) not substrate specific 4) Enzymes present in viruses
Ans: 2
32. Following myocardial infraction, the earliest serum enzymes to rise is:
1) creatine kinase 2) glutamate oxaloacetate transaminase
3) glutamate pyruvate transaminase 4) Lactate dehydrogenase
Ans: 1
33. Following myocardial infraction, serum creatine kinase returns to normal in about
1) 24 hrs 2) 3 days 3) 5 days 4) 7 days
Ans: 2
34. Cyanide inhibits the following complex of respiratory chain:
1) Complex II 2) Complex III 3) Complex IV 4) Complex V
Ans: 3
35. cytochrome oxidase is poisoned by the following except
1) oligomycin 2) hydrogen sulphide 3) carbon monoxide 4) cyanide
Ans: 1
36. Large doses of niacin
1) Increase serum cholesterol 2) decrease serum cholesterol
3) Increase serum pyruvate 4) decrease serum pyruvate
Ans: 2
37. Sigmoidal oxygen dissociation curve is property of:
1) Haemoglobin 2) carboxyhaemoglobin 3) myoglobin 4) Methaemoglobin
Ans: 1
38. Kernicterus can occur in :
1) Crigler-Najjar syndrome type I 2) Crigler-Najjar syndrome type II
3) Rotor's syndrome 4) Gilbert's syndrome
Ans: 1
39. Glucose is the only source of energy for:
1) Myocardium 2) Kidneys 3) Erythrocytes 4) Thrombocytes
Ans: 3
40. Dipalmitoyl Lecithin acts as:
1) Platelet activating factors 2) second messenger for hormones
3) lung surfactant 4) anti ketogenic compound
Ans: 3
41. Synthesis of prostaglandins is inhibited by:
1) Glucocorticoids 2) Glucagon 3) Insulin 4) Progesterone
Ans: 1
42. Aspirin inhibits:
1) Phospholipase C 2) Phospholipase D 3) Cyclo-oxygenase 4) Lipo-oxygenase
Ans: 3
43. Hyperuricaemia can occur due to all the following except
1) superactive phosphoribosyl pyrophosphate synthetase
2) hypoxanthine guanine phosphoribosyl transferase deficiency
3) Glucose-6 phophatase deficiency
4) Uricase deficiency
Ans: 4
44. Severe combined immunodeficiency disease (SCID)can result from deficiency
1) Adenosine kinase
2) Adenosine deaminase
3) Adenine phosphorobosyl transferase
4) hypoxanthine guanine phosphorobosyl transferase
Ans: 2
45. All the following can occur in Lesch-Nyhan syndrome except
1) Gouty arthritis 2) Uric acid stones 3) Retarded growth 4) Self- mutilating behavior
Ans: 3
46. Cyclins:
1) are circular DNA double helices 2) are circular polypeptides
3) are protein that regulates cell cycle 4) can undergo phosphorylation and dephosphorylations
Ans: 3
47. Rifampicin inhibits:
1) Unbinding of DNA 2) Initiation of replication 3) Initiation of translation 4) Initiation of transcription
Ans: 4
48. Peptidyl transferase activity of 50 S ribosomal subunits is inhibited by :
1) Rifampicin 2) Cycloheximide 3) Erythromycin 4) Chloramphenicol
Ans: 4
49. Inhibitors of mono amine oxidase prolong the life of :
1) gamma-aminobutyric acid 2) Melanin 3) Melatonin 4) Serotonin
Ans: 4
50. An extracellular fluid having a higher concentration of chloride than serum is
1) Bile 2) Sweat 3) Cerebrospinal fluid 4) Pancreatic juice
Ans: 3
51. Zinc deficiency occurs commonly in:
1) Acrodermatitis enteropathica 2) Wilson's disease 3) Xeroderma pigmentosum 4) Menkes' disease
Ans: 1
52. Autoimmune disease occurs due to
1) impairment of humoral immunity 2) Impairment of cell-mediated immunity
3) Adaptive immune response against self molecules 4) innate immune response against self molecules
Ans: 3
53. The antibody that acts against helminths is
1) IgA 2) IgE 3) IgG 4) IgM
Ans: 2
54. The limiting amino acid in pulses is:
1) Leucine 2) Lysine 3) Tryptophan 4) Methionine
Ans: 4
55. Protein kinase C is activated by:
1) Diacyl glycerol 2) Inositol triphosphate 3) cyclic AMP 4) cyclic GMP
Ans: 1
56. Ames' assay is a rapid method for detection of
1) Oncoviruses 2) retroviruses 3) Chemical carcinogens 4) typhoid
Ans: 3
57. Conversion of procarcinogen into a carcinogen ofter requires
1) Proteolysis 2) Cytochrome p-450 3) Exposure to ultra-violet radiation 4) Exposure to X-rays
Ans: 2
58. Isoelectric pH of Albumin is:
1) 4.7 2) 5.7 3) 6.7 4) 7.7
Ans: 1
59. Donor of methyl group for the conversion of norepinephrine to epinephrine is:
1) cAMP 2) GTP 3) CoASH 4) SAM
Ans: 4
60. Squalene is a compound having carbon atoms :
1) 20 2) 27 3) 30 4) 37
Ans: 3
61. How many amino acids are present in the structure of glucagon hormone?
1) 29 2) 39 3) 49 4) 59
Ans: 1
62:-Which one of the following is NOT true regarding IgM?
A:-Do not fix complement B:-Antigen receptor is on the surface of B cells
C:-Do not cross the placenta D:-Involved in primary response
Ans: A
63:-Which amino acid is relatively absent in alpha helices?
A:-Glycine B:-Valine C:-Tryptophan D:-Arginine
Ans: A
64:-Which one of the following diseases is due to defective collagen synthesis?
A:-Leukocyte adhesion deficiency II B:-Ehlers-Danlos syndrome
C:-Paroxysmal nocturnal hemoglobinuria D:-I-cell disease
Ans: B
65:-Which of the following vitamins provide the cofactor for transketolase reaction?
A:-Vitamin `"B_6"` B:-Niacin C:-Thiamine D:-Riboflavin
Ans: C
66:-Which one of the following histone amino acid is typically acetylated?
A:-Lysine B:-Arginine C:-Histidine D:-Leucine
Ans: A
67:-Vitamin C is not synthesized in humans due to the deficiency of ____________.
A:-L-Xylulose dehydrogenase B:-L-Gulonolactone oxidase C:-L-Gulonate oxidase D:-D-Glucuronate reductase
Ans: B
68:-In the human body isoniazid is detoxified by _____________.
A:-Acetylation B:-Methylation C:-Conjugation with sulphate D:-Conjugation with glycine
Ans: A
69:-During protein synthesis which amino acid is incorporated first in eukaryotes?
A:-N-formyl methionine B:-Methionine C:-Phenyl alanine D:-Glutamine
Ans: B
70:-All the following are features of kwashiorkor EXCEPT
A:-Lethargic and apathetic B:-Presence of anorexia C:-Crazy pavement dermatitis D:-Serum albumin 2 to 3 g/dl
Ans: D
71:-The reference interval for plasma osmolality is
A:-150 to 175 mOsmol/Kg B:-300 to 325 mOsmol/L C:-275 to 300 mOsmol/Kg D:-350 to 375 mOsmol/L
Ans: C
72:-Which one of the following is a marker of bone resorption?
A:-Procollagen typeI N-terminal propeptide B:-C-telopeptide C:-Osteocalcin D:-Bone alkaline phosphatase
Ans: B
73:-Specific dynamic action for protein is
A:-5% B:-15% C:-30% D:-55%
Ans: C
74:-Which of the following is NOT a constituent of human glycoproteins?
A:-Glucose B:-Fucose C:-Xylose D:-Sucrose
Ans: D
75:-In which of the following condition CSF glucose is normal?
A:-Bacterial meningitis B:-Tuberculous meningitis C:-Viral meningitis D:-Brain tumor
Ans: C
76:-Which one of the following statements is FALSE regarding nitric oxide?
A:-Asparagine is the precursor of nitric oxide B:-Is a potent vasodilator
C:-Depresses platelet function D:-Results in refractory hypotension in septicemia
Ans: A
77:-Westgard multirule `4_{1s}` is sensitive to which type of analytical error?
A:-Systematic error B:-Imprecision error C:-Random error D:-Standardization error
Ans: A
78:-Which is the optical technique that measures the emitted light by a species that has absorbed exciting radiation from an outside source?
A:-Spectrophotometry B:-Reflectance photometry
C:-Fluorometry D:-Nephelometry
Ans: C
79:-In which condition is a decrease in serum albumin and an increase in alpha2-macroglobulin seen?
A:-Cirrhosis B:-Inflammation C:-Multiple myeloma D:-Nephrotic syndrome
Ans: D
80:-The most common biological recognition element used in a biosensor is
A:-Antigen B:-Antibody C:-Enzyme D:-Hormone
Ans: C
81:-Which of the following is the marker enzyme of microsomes?
A:-Cathepsin B:-Galactosyl transferase C:-Catalase D:-Glucose-6-phosphatase
Ans: D
82:-Hill equation explains
A:-Bi-bi reaction of enzymes B:-Co-operative binding of enzymes
C:-Ping-pong mechanism of enzymes D:-Suicidal inhibition of enzymes
Ans: B
83:-Select the glycosaminoglycan which does not contain uronic acid.
A:-Keratan sulfate B:-Chondroitin sulfate C:-Dermatan sulfate D:-Hyaluronic acid
Ans: A
84:-Which of the following is NOT true regarding 2,3-BPG?
A:-Stabilizes the T structure of hemoglobin B:-`"CO_2"` increases the synthesis of 2,3-BPG
C:-2,3-BPG binds strongly to HbF than HbA D:-At high altitude the synthesis of 2,3-BPG is increased
Ans: C
85:-Which of the following test is NOT used for the diagnosis of secondary adrenal insufficiency?
A:-Dexamethasone suppression test B:-Cosyntropin test
C:-Overnight metyrapone test D:-Insulin tolerance test
Ans: A
86:-All the following hormones bind to cell surface receptors EXCEPT
A:-Insulin B:-Substance P C:-Thyroid hormone D:-Glucagon
Ans: C
87:-Which of the following hormone is NOT stored in the cells?
A:-Parathormone B:-Aldosterone C:-Insulin D:-Adrenalin
Ans: B
88:-Select the enzyme that is deficient in classical homocystinuria.
A:-Adenosine homocysteinase B:-Homocysteine methyl transferase
C:-Cystathionine beta synthase D:-Cystathionase
Ans: C
89:-Which one of the following hormone is appetite suppressant?
A:-Leptin B:-Ghrelin C:-Glucagon D:-Rennin
Ans: A
90:-Which of the following is NOT a high energy compound?
A:-Creatine phosphate B:-1,3-bisphosphoglycerate C:-Glucose-6-phosphate D:-Carbamoyl phosphate
Ans: C
91:-Which of the following is an excellent GFR marker?
A:-Creatinine clearance B:-Cystatin C C:-Tamm Horsfall glycoprotein D:-Inulin clearance
Ans: B
92:-Which one of the following enzyme catalyzes a substrate level phosphorylation reaction?
A:-Phosphofructokinase B:-Glucokinase C:-Succinate thiokinase D:-Succinate dehydrogenase
Ans: C
93:-Which one of the following is a selenium containing enzyme?
A:-5' deiodinase B:-Thyroperoxidase C:-Xanthine oxidase D:-Glutamate dehydrogenase
Ans: A
94:-Select the enzyme that is deficient in Lesch-Nyhan syndrome
A:-Phosphoribosyl amidotransferase B:-Hypoxanthine guanine phosphoribosyl transferase
C:-Adenine phosphoribosyl transferase D:-Phosphoribosyl pyrophosphate synthase
Ans: B
95:-Cataract in galactosemia is due to accumulation of
A:-Dulcitol in lens B:-Sorbitol in lens C:-Mannitol in lens D:-Iduronic acid in lens
Ans: A
96:-Which one of the following apoproteins is present in LDL?
A:-Apo B-48 B:-Apo B-100 C:-Apo E D:-Apo C
Ans: B
97:-All the following are autosomal recessive diseases EXCEPT
A:-Albinism B:-Sickle cell anemia C:-Chondrodystrophy D:-Phenyl ketonuria
Ans: C
98:-Which one of the following is NOT a substrate for gluconeogenesis?
A:-Glycerol B:-Propionyl CoA C:-Even chain fatty acids D:-Lactate
Ans: C
99:-The size of Okazaki segments synthesized on lagging strand of bacterial DNA is approximately
A:-100 - 200 nucleotides
B:-100 - 200 base pairs
C:-1000 - 2000 nucleotides
D:-1000 - 2000 base pairs
Ans: C
100:-Galactosemia
A:-is a genetic deficiency of a uridylyltransferase that exchanges galactose 1-phosphate for glucose on UDP-glucose
B:-results from a deficiency of an epimerase
C:-is not apparent at birth but symptoms develop in later life
D:-is an inability to form galactose 1-phosphate
Ans: A
1) Acrodermatitis enteropathica 2) Wilson's disease 3) Xeroderma pigmentosum 4) Menkes' disease
Ans: 1
52. Autoimmune disease occurs due to
1) impairment of humoral immunity 2) Impairment of cell-mediated immunity
3) Adaptive immune response against self molecules 4) innate immune response against self molecules
Ans: 3
53. The antibody that acts against helminths is
1) IgA 2) IgE 3) IgG 4) IgM
Ans: 2
54. The limiting amino acid in pulses is:
1) Leucine 2) Lysine 3) Tryptophan 4) Methionine
Ans: 4
55. Protein kinase C is activated by:
1) Diacyl glycerol 2) Inositol triphosphate 3) cyclic AMP 4) cyclic GMP
Ans: 1
56. Ames' assay is a rapid method for detection of
1) Oncoviruses 2) retroviruses 3) Chemical carcinogens 4) typhoid
Ans: 3
57. Conversion of procarcinogen into a carcinogen ofter requires
1) Proteolysis 2) Cytochrome p-450 3) Exposure to ultra-violet radiation 4) Exposure to X-rays
Ans: 2
58. Isoelectric pH of Albumin is:
1) 4.7 2) 5.7 3) 6.7 4) 7.7
Ans: 1
59. Donor of methyl group for the conversion of norepinephrine to epinephrine is:
1) cAMP 2) GTP 3) CoASH 4) SAM
Ans: 4
60. Squalene is a compound having carbon atoms :
1) 20 2) 27 3) 30 4) 37
Ans: 3
61. How many amino acids are present in the structure of glucagon hormone?
1) 29 2) 39 3) 49 4) 59
Ans: 1
62:-Which one of the following is NOT true regarding IgM?
A:-Do not fix complement B:-Antigen receptor is on the surface of B cells
C:-Do not cross the placenta D:-Involved in primary response
Ans: A
63:-Which amino acid is relatively absent in alpha helices?
A:-Glycine B:-Valine C:-Tryptophan D:-Arginine
Ans: A
64:-Which one of the following diseases is due to defective collagen synthesis?
A:-Leukocyte adhesion deficiency II B:-Ehlers-Danlos syndrome
C:-Paroxysmal nocturnal hemoglobinuria D:-I-cell disease
Ans: B
65:-Which of the following vitamins provide the cofactor for transketolase reaction?
A:-Vitamin `"B_6"` B:-Niacin C:-Thiamine D:-Riboflavin
Ans: C
66:-Which one of the following histone amino acid is typically acetylated?
A:-Lysine B:-Arginine C:-Histidine D:-Leucine
Ans: A
67:-Vitamin C is not synthesized in humans due to the deficiency of ____________.
A:-L-Xylulose dehydrogenase B:-L-Gulonolactone oxidase C:-L-Gulonate oxidase D:-D-Glucuronate reductase
Ans: B
68:-In the human body isoniazid is detoxified by _____________.
A:-Acetylation B:-Methylation C:-Conjugation with sulphate D:-Conjugation with glycine
Ans: A
69:-During protein synthesis which amino acid is incorporated first in eukaryotes?
A:-N-formyl methionine B:-Methionine C:-Phenyl alanine D:-Glutamine
Ans: B
70:-All the following are features of kwashiorkor EXCEPT
A:-Lethargic and apathetic B:-Presence of anorexia C:-Crazy pavement dermatitis D:-Serum albumin 2 to 3 g/dl
Ans: D
71:-The reference interval for plasma osmolality is
A:-150 to 175 mOsmol/Kg B:-300 to 325 mOsmol/L C:-275 to 300 mOsmol/Kg D:-350 to 375 mOsmol/L
Ans: C
72:-Which one of the following is a marker of bone resorption?
A:-Procollagen typeI N-terminal propeptide B:-C-telopeptide C:-Osteocalcin D:-Bone alkaline phosphatase
Ans: B
73:-Specific dynamic action for protein is
A:-5% B:-15% C:-30% D:-55%
Ans: C
74:-Which of the following is NOT a constituent of human glycoproteins?
A:-Glucose B:-Fucose C:-Xylose D:-Sucrose
Ans: D
75:-In which of the following condition CSF glucose is normal?
A:-Bacterial meningitis B:-Tuberculous meningitis C:-Viral meningitis D:-Brain tumor
Ans: C
76:-Which one of the following statements is FALSE regarding nitric oxide?
A:-Asparagine is the precursor of nitric oxide B:-Is a potent vasodilator
C:-Depresses platelet function D:-Results in refractory hypotension in septicemia
Ans: A
77:-Westgard multirule `4_{1s}` is sensitive to which type of analytical error?
A:-Systematic error B:-Imprecision error C:-Random error D:-Standardization error
Ans: A
78:-Which is the optical technique that measures the emitted light by a species that has absorbed exciting radiation from an outside source?
A:-Spectrophotometry B:-Reflectance photometry
C:-Fluorometry D:-Nephelometry
Ans: C
79:-In which condition is a decrease in serum albumin and an increase in alpha2-macroglobulin seen?
A:-Cirrhosis B:-Inflammation C:-Multiple myeloma D:-Nephrotic syndrome
Ans: D
80:-The most common biological recognition element used in a biosensor is
A:-Antigen B:-Antibody C:-Enzyme D:-Hormone
Ans: C
81:-Which of the following is the marker enzyme of microsomes?
A:-Cathepsin B:-Galactosyl transferase C:-Catalase D:-Glucose-6-phosphatase
Ans: D
82:-Hill equation explains
A:-Bi-bi reaction of enzymes B:-Co-operative binding of enzymes
C:-Ping-pong mechanism of enzymes D:-Suicidal inhibition of enzymes
Ans: B
83:-Select the glycosaminoglycan which does not contain uronic acid.
A:-Keratan sulfate B:-Chondroitin sulfate C:-Dermatan sulfate D:-Hyaluronic acid
Ans: A
84:-Which of the following is NOT true regarding 2,3-BPG?
A:-Stabilizes the T structure of hemoglobin B:-`"CO_2"` increases the synthesis of 2,3-BPG
C:-2,3-BPG binds strongly to HbF than HbA D:-At high altitude the synthesis of 2,3-BPG is increased
Ans: C
85:-Which of the following test is NOT used for the diagnosis of secondary adrenal insufficiency?
A:-Dexamethasone suppression test B:-Cosyntropin test
C:-Overnight metyrapone test D:-Insulin tolerance test
Ans: A
86:-All the following hormones bind to cell surface receptors EXCEPT
A:-Insulin B:-Substance P C:-Thyroid hormone D:-Glucagon
Ans: C
87:-Which of the following hormone is NOT stored in the cells?
A:-Parathormone B:-Aldosterone C:-Insulin D:-Adrenalin
Ans: B
88:-Select the enzyme that is deficient in classical homocystinuria.
A:-Adenosine homocysteinase B:-Homocysteine methyl transferase
C:-Cystathionine beta synthase D:-Cystathionase
Ans: C
89:-Which one of the following hormone is appetite suppressant?
A:-Leptin B:-Ghrelin C:-Glucagon D:-Rennin
Ans: A
90:-Which of the following is NOT a high energy compound?
A:-Creatine phosphate B:-1,3-bisphosphoglycerate C:-Glucose-6-phosphate D:-Carbamoyl phosphate
Ans: C
91:-Which of the following is an excellent GFR marker?
A:-Creatinine clearance B:-Cystatin C C:-Tamm Horsfall glycoprotein D:-Inulin clearance
Ans: B
92:-Which one of the following enzyme catalyzes a substrate level phosphorylation reaction?
A:-Phosphofructokinase B:-Glucokinase C:-Succinate thiokinase D:-Succinate dehydrogenase
Ans: C
93:-Which one of the following is a selenium containing enzyme?
A:-5' deiodinase B:-Thyroperoxidase C:-Xanthine oxidase D:-Glutamate dehydrogenase
Ans: A
94:-Select the enzyme that is deficient in Lesch-Nyhan syndrome
A:-Phosphoribosyl amidotransferase B:-Hypoxanthine guanine phosphoribosyl transferase
C:-Adenine phosphoribosyl transferase D:-Phosphoribosyl pyrophosphate synthase
Ans: B
95:-Cataract in galactosemia is due to accumulation of
A:-Dulcitol in lens B:-Sorbitol in lens C:-Mannitol in lens D:-Iduronic acid in lens
Ans: A
96:-Which one of the following apoproteins is present in LDL?
A:-Apo B-48 B:-Apo B-100 C:-Apo E D:-Apo C
Ans: B
97:-All the following are autosomal recessive diseases EXCEPT
A:-Albinism B:-Sickle cell anemia C:-Chondrodystrophy D:-Phenyl ketonuria
Ans: C
98:-Which one of the following is NOT a substrate for gluconeogenesis?
A:-Glycerol B:-Propionyl CoA C:-Even chain fatty acids D:-Lactate
Ans: C
99:-The size of Okazaki segments synthesized on lagging strand of bacterial DNA is approximately
A:-100 - 200 nucleotides
B:-100 - 200 base pairs
C:-1000 - 2000 nucleotides
D:-1000 - 2000 base pairs
Ans: C
100:-Galactosemia
A:-is a genetic deficiency of a uridylyltransferase that exchanges galactose 1-phosphate for glucose on UDP-glucose
B:-results from a deficiency of an epimerase
C:-is not apparent at birth but symptoms develop in later life
D:-is an inability to form galactose 1-phosphate
Ans: A